The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism
The vitamin K antagonist is a commonly prescribed effective oral anticoagulant with a narrow therapeutic range, and the dose requirements for different patients varied greatly. In recent years, studies on human intestinal microbiome have provided many valuable insights into disease development and d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.829304/full |
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| author | Han Yan Yi Chen Yi Chen Yi Chen Hong Zhu Hong Zhu Wei-Hua Huang Wei-Hua Huang Wei-Hua Huang Xin-He Cai Xin-He Cai Xin-He Cai Dan Li Dan Li Dan Li Ya-Juan Lv Ya-Juan Lv Ya-Juan Lv Si-Zhao Si-Zhao Si-Zhao Hong-Hao Zhou Hong-Hao Zhou Hong-Hao Zhou Fan-Yan Luo Fan-Yan Luo Wei Zhang Wei Zhang Wei Zhang Xi Li Xi Li Xi Li |
| author_facet | Han Yan Yi Chen Yi Chen Yi Chen Hong Zhu Hong Zhu Wei-Hua Huang Wei-Hua Huang Wei-Hua Huang Xin-He Cai Xin-He Cai Xin-He Cai Dan Li Dan Li Dan Li Ya-Juan Lv Ya-Juan Lv Ya-Juan Lv Si-Zhao Si-Zhao Si-Zhao Hong-Hao Zhou Hong-Hao Zhou Hong-Hao Zhou Fan-Yan Luo Fan-Yan Luo Wei Zhang Wei Zhang Wei Zhang Xi Li Xi Li Xi Li |
| author_sort | Han Yan |
| collection | DOAJ |
| description | The vitamin K antagonist is a commonly prescribed effective oral anticoagulant with a narrow therapeutic range, and the dose requirements for different patients varied greatly. In recent years, studies on human intestinal microbiome have provided many valuable insights into disease development and drug reactions. A lot of studies indicated the potential relationship between microbiome and the vitamin K antagonist. Vitamin K is absorbed by the gut, and the intestinal bacteria are a major source of vitamin K in human body. A combined use of the vitamin K antagonist and antibiotics may result in an increase in INR, thus elevating the risk of bleeding, while vitamin K supplementation can improve stability of anticoagulation for oral vitamin K antagonist treatment. Recently, how intestinal bacteria affect the response of the vitamin K antagonist remains unclear. In this review, we reviewed the research, focusing on the physiology of vitamin K in the anticoagulation treatment, and investigated the potential pathways of intestinal bacteria affecting the reaction of the vitamin K antagonist. |
| first_indexed | 2024-04-13T06:46:51Z |
| format | Article |
| id | doaj.art-c675a17bfbde4721a50cff439d0ae901 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T06:46:51Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-c675a17bfbde4721a50cff439d0ae9012022-12-22T02:57:33ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-04-01910.3389/fmed.2022.829304829304The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential MechanismHan Yan0Yi Chen1Yi Chen2Yi Chen3Hong Zhu4Hong Zhu5Wei-Hua Huang6Wei-Hua Huang7Wei-Hua Huang8Xin-He Cai9Xin-He Cai10Xin-He Cai11Dan Li12Dan Li13Dan Li14Ya-Juan Lv15Ya-Juan Lv16Ya-Juan Lv17 Si-Zhao18 Si-Zhao19 Si-Zhao20Hong-Hao Zhou21Hong-Hao Zhou22Hong-Hao Zhou23Fan-Yan Luo24Fan-Yan Luo25Wei Zhang26Wei Zhang27Wei Zhang28Xi Li29Xi Li30Xi Li31Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaThe vitamin K antagonist is a commonly prescribed effective oral anticoagulant with a narrow therapeutic range, and the dose requirements for different patients varied greatly. In recent years, studies on human intestinal microbiome have provided many valuable insights into disease development and drug reactions. A lot of studies indicated the potential relationship between microbiome and the vitamin K antagonist. Vitamin K is absorbed by the gut, and the intestinal bacteria are a major source of vitamin K in human body. A combined use of the vitamin K antagonist and antibiotics may result in an increase in INR, thus elevating the risk of bleeding, while vitamin K supplementation can improve stability of anticoagulation for oral vitamin K antagonist treatment. Recently, how intestinal bacteria affect the response of the vitamin K antagonist remains unclear. In this review, we reviewed the research, focusing on the physiology of vitamin K in the anticoagulation treatment, and investigated the potential pathways of intestinal bacteria affecting the reaction of the vitamin K antagonist.https://www.frontiersin.org/articles/10.3389/fmed.2022.829304/fullvitamin Kintestinal bacteriabutyratevitamin K antagonistlithocholic acid |
| spellingShingle | Han Yan Yi Chen Yi Chen Yi Chen Hong Zhu Hong Zhu Wei-Hua Huang Wei-Hua Huang Wei-Hua Huang Xin-He Cai Xin-He Cai Xin-He Cai Dan Li Dan Li Dan Li Ya-Juan Lv Ya-Juan Lv Ya-Juan Lv Si-Zhao Si-Zhao Si-Zhao Hong-Hao Zhou Hong-Hao Zhou Hong-Hao Zhou Fan-Yan Luo Fan-Yan Luo Wei Zhang Wei Zhang Wei Zhang Xi Li Xi Li Xi Li The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism Frontiers in Medicine vitamin K intestinal bacteria butyrate vitamin K antagonist lithocholic acid |
| title | The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism |
| title_full | The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism |
| title_fullStr | The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism |
| title_full_unstemmed | The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism |
| title_short | The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism |
| title_sort | relationship among intestinal bacteria vitamin k and response of vitamin k antagonist a review of evidence and potential mechanism |
| topic | vitamin K intestinal bacteria butyrate vitamin K antagonist lithocholic acid |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.829304/full |
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