Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro evaluation of their growth inhibitory activity towards the proliferation of three cancer cell lines; HepG2 (hepatocell...

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Bibliographic Details
Main Authors: Ahmed Sabt, Omaima M. Abdelhafez, Radwan S. El-Haggar, Hassan M. F. Madkour, Wagdy M. Eldehna, Ezz El-Din A. M. El-Khrisy, Mohamed A. Abdel-Rahman, Laila. A. Rashed
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Anticancer
Apoptosis
Coumarin-6-sulfonamides
2D-QSAR
Synthesis
Online Access:http://dx.doi.org/10.1080/14756366.2018.1477137

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