Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose
A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1–42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory eff...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2008-01-01
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| Series: | Science and Technology of Advanced Materials |
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| Online Access: | http://www.iop.org/EJ/abstract/1468-6996/9/2/024407 |
| _version_ | 1818241072260710400 |
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| author | Yoshiko Miura et al |
| author_facet | Yoshiko Miura et al |
| author_sort | Yoshiko Miura et al |
| collection | DOAJ |
| description | A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1–42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by in vitro assay using HeLa cells. The glycopolymer carrying trehalose strongly inhibited amyloid formation and neutralized cytotoxicity. |
| first_indexed | 2024-12-12T13:23:31Z |
| format | Article |
| id | doaj.art-c675bca668584fd58d2a6af72ff30b96 |
| institution | Directory Open Access Journal |
| issn | 1468-6996 1878-5514 |
| language | English |
| last_indexed | 2024-12-12T13:23:31Z |
| publishDate | 2008-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Science and Technology of Advanced Materials |
| spelling | doaj.art-c675bca668584fd58d2a6af72ff30b962022-12-22T00:23:14ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142008-01-0192024407Inhibition of Alzheimer amyloid β aggregation by polyvalent trehaloseYoshiko Miura et alA glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1–42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by in vitro assay using HeLa cells. The glycopolymer carrying trehalose strongly inhibited amyloid formation and neutralized cytotoxicity.http://www.iop.org/EJ/abstract/1468-6996/9/2/024407glycopolymeramyloidmultivalent effectamphiphilicity |
| spellingShingle | Yoshiko Miura et al Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose Science and Technology of Advanced Materials glycopolymer amyloid multivalent effect amphiphilicity |
| title | Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose |
| title_full | Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose |
| title_fullStr | Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose |
| title_full_unstemmed | Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose |
| title_short | Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose |
| title_sort | inhibition of alzheimer amyloid β aggregation by polyvalent trehalose |
| topic | glycopolymer amyloid multivalent effect amphiphilicity |
| url | http://www.iop.org/EJ/abstract/1468-6996/9/2/024407 |
| work_keys_str_mv | AT yoshikomiuraetal inhibitionofalzheimeramyloidbaggregationbypolyvalenttrehalose |