Genome-wide meta-QTL analyses provide novel insight into disease resistance repertoires in common bean
Abstract Background Common bean (Phaseolus vulgaris) is considered a staple food in a number of developing countries. Several diseases attack the crop leading to substantial economic losses around the globe. However, the crop has rarely been investigated for multiple disease resistance traits using...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-022-08914-w |
| _version_ | 1811226695719452672 |
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| author | Asma Rahmanzadeh Bahman Khahani S. Mohsen Taghavi Moein Khojasteh Ebrahim Osdaghi |
| author_facet | Asma Rahmanzadeh Bahman Khahani S. Mohsen Taghavi Moein Khojasteh Ebrahim Osdaghi |
| author_sort | Asma Rahmanzadeh |
| collection | DOAJ |
| description | Abstract Background Common bean (Phaseolus vulgaris) is considered a staple food in a number of developing countries. Several diseases attack the crop leading to substantial economic losses around the globe. However, the crop has rarely been investigated for multiple disease resistance traits using Meta-analysis approach. Results and conclusions In this study, in order to identify the most reliable and stable quantitative trait loci (QTL) conveying disease resistance in common bean, we carried out a meta-QTL (MQTL) analysis using 152 QTLs belonging to 44 populations reported in 33 publications within the past 20 years. These QTLs were decreased into nine MQTLs and the average of confidence interval (CI) was reduced by 2.64 folds with an average of 5.12 cM in MQTLs. Uneven distribution of MQTLs across common bean genome was noted where sub-telomeric regions carry most of the corresponding genes and MQTLs. One MQTL was identified to be specifically associated with resistance to halo blight disease caused by the bacterial pathogen Pseudomonas savastanoi pv. phaseolicola, while three and one MQTLs were specifically associated with resistance to white mold and anthracnose caused by the fungal pathogens Sclerotinia sclerotiorum and Colletotrichum lindemuthianum, respectively. Furthermore, two MQTLs were detected governing resistance to halo blight and anthracnose, while two MQTLs were detected for resistance against anthracnose and white mold, suggesting putative genes governing resistance against these diseases at a shared locus. Comparative genomics and synteny analyses provide a valuable strategy to identify a number of well‑known functionally described genes as well as numerous putative novels candidate genes in common bean, Arabidopsis and soybean genomes. |
| first_indexed | 2024-04-12T09:29:40Z |
| format | Article |
| id | doaj.art-c676248b03ba4c69ac74717f3fb76f58 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-04-12T09:29:40Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-c676248b03ba4c69ac74717f3fb76f582022-12-22T03:38:24ZengBMCBMC Genomics1471-21642022-10-0123111810.1186/s12864-022-08914-wGenome-wide meta-QTL analyses provide novel insight into disease resistance repertoires in common beanAsma Rahmanzadeh0Bahman Khahani1S. Mohsen Taghavi2Moein Khojasteh3Ebrahim Osdaghi4Department of Plant Protection, School of Agriculture, Shiraz UniversityDepartment of Plant Genetics and Production, College of Agriculture, Shiraz UniversityDepartment of Plant Protection, School of Agriculture, Shiraz UniversityDepartment of Plant Protection, School of Agriculture, Shiraz UniversityDepartment of Plant Protection, College of Agriculture, University of TehranAbstract Background Common bean (Phaseolus vulgaris) is considered a staple food in a number of developing countries. Several diseases attack the crop leading to substantial economic losses around the globe. However, the crop has rarely been investigated for multiple disease resistance traits using Meta-analysis approach. Results and conclusions In this study, in order to identify the most reliable and stable quantitative trait loci (QTL) conveying disease resistance in common bean, we carried out a meta-QTL (MQTL) analysis using 152 QTLs belonging to 44 populations reported in 33 publications within the past 20 years. These QTLs were decreased into nine MQTLs and the average of confidence interval (CI) was reduced by 2.64 folds with an average of 5.12 cM in MQTLs. Uneven distribution of MQTLs across common bean genome was noted where sub-telomeric regions carry most of the corresponding genes and MQTLs. One MQTL was identified to be specifically associated with resistance to halo blight disease caused by the bacterial pathogen Pseudomonas savastanoi pv. phaseolicola, while three and one MQTLs were specifically associated with resistance to white mold and anthracnose caused by the fungal pathogens Sclerotinia sclerotiorum and Colletotrichum lindemuthianum, respectively. Furthermore, two MQTLs were detected governing resistance to halo blight and anthracnose, while two MQTLs were detected for resistance against anthracnose and white mold, suggesting putative genes governing resistance against these diseases at a shared locus. Comparative genomics and synteny analyses provide a valuable strategy to identify a number of well‑known functionally described genes as well as numerous putative novels candidate genes in common bean, Arabidopsis and soybean genomes.https://doi.org/10.1186/s12864-022-08914-wAntrachnoseHalo blightMeta-analysisPhaseolus vulgarisQuantitative trait lociWhite mold |
| spellingShingle | Asma Rahmanzadeh Bahman Khahani S. Mohsen Taghavi Moein Khojasteh Ebrahim Osdaghi Genome-wide meta-QTL analyses provide novel insight into disease resistance repertoires in common bean BMC Genomics Antrachnose Halo blight Meta-analysis Phaseolus vulgaris Quantitative trait loci White mold |
| title | Genome-wide meta-QTL analyses provide novel insight into disease resistance repertoires in common bean |
| title_full | Genome-wide meta-QTL analyses provide novel insight into disease resistance repertoires in common bean |
| title_fullStr | Genome-wide meta-QTL analyses provide novel insight into disease resistance repertoires in common bean |
| title_full_unstemmed | Genome-wide meta-QTL analyses provide novel insight into disease resistance repertoires in common bean |
| title_short | Genome-wide meta-QTL analyses provide novel insight into disease resistance repertoires in common bean |
| title_sort | genome wide meta qtl analyses provide novel insight into disease resistance repertoires in common bean |
| topic | Antrachnose Halo blight Meta-analysis Phaseolus vulgaris Quantitative trait loci White mold |
| url | https://doi.org/10.1186/s12864-022-08914-w |
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