LOCAL APPLICATION OF TRANEXAMIC ACID IN KNEE REPLACEMENT
The purpose of the study – assessment of the efficacy of local application of tranexamic acid in TKA and the choice of the optimal dosage. Materials and methods. 48 patients were included in open-prospective study and were randomized to one of four groups. In the first group tranexamic acid was used...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Vreden Russian Research Institute of Traumatology and Orthopedics
2016-12-01
|
| Series: | Travmatologiâ i Ortopediâ Rossii |
| Subjects: | |
| Online Access: | https://journal.rniito.org/jour/article/view/634 |
| _version_ | 1818642701957988352 |
|---|---|
| author | E. V. Pshenitsyna V. I. Zagrekov E. E. Malyshev |
| author_facet | E. V. Pshenitsyna V. I. Zagrekov E. E. Malyshev |
| author_sort | E. V. Pshenitsyna |
| collection | DOAJ |
| description | The purpose of the study – assessment of the efficacy of local application of tranexamic acid in TKA and the choice of the optimal dosage. Materials and methods. 48 patients were included in open-prospective study and were randomized to one of four groups. In the first group tranexamic acid was used as intravenous bolus at the beginning of the operation at a dose of 15 mg/kg. Additionally, after the installation of the prosthetic components, the surgeon performed periarticular infiltration of soft tissue by tranexamic acid solution at a dose of 15 mg/kg. In the second group of patients tranexamic acid was used as 500 mg intravenous bolus before surgery, and 500 mg locally after installation of the prosthesis components. In the third group of patients received tranexamic acid once at the beginning of the operation at a dose of 15 mg/kg iv bolus. In the fourth group tranexam was used after surgery once at a dose of 10 mg/kg. Results. In the first group of patients were achieved statistically significant, 5-6 times, reduction of blood loss on drainage in comparison with other groups, where the volume of postoperative blood loss was not significantly different between groups. Also in the first group recorded the smallest decrease in hemoglobin at the 5th postoperative day compared to the third and fourth groups. Complications associated with the use of tranexamic acid were not revealed. Conclusion. The method of periarticular infiltration by tranexamic acid in combination with its intravenous use in knee joint replacement is an effective and safe method for reduction of post-operative blood loss. |
| first_indexed | 2024-12-16T23:47:15Z |
| format | Article |
| id | doaj.art-c67a183659ab487eb68cd0da8bce4976 |
| institution | Directory Open Access Journal |
| issn | 2311-2905 2542-0933 |
| language | Russian |
| last_indexed | 2024-12-16T23:47:15Z |
| publishDate | 2016-12-01 |
| publisher | Vreden Russian Research Institute of Traumatology and Orthopedics |
| record_format | Article |
| series | Travmatologiâ i Ortopediâ Rossii |
| spelling | doaj.art-c67a183659ab487eb68cd0da8bce49762022-12-21T22:11:27ZrusVreden Russian Research Institute of Traumatology and OrthopedicsTravmatologiâ i Ortopediâ Rossii2311-29052542-09332016-12-01224162410.21823/2311-2905-2016-22-4-16-24596LOCAL APPLICATION OF TRANEXAMIC ACID IN KNEE REPLACEMENTE. V. Pshenitsyna0V. I. Zagrekov1E. E. Malyshev2Privolzhsky Federal Research Medical Centre 18, Verkhne-Volzhskaya nab., Nizhny Novgorod, 603155, RussiaPrivolzhsky Federal Research Medical Centre 18, Verkhne-Volzhskaya nab., Nizhny Novgorod, 603155, RussiaPrivolzhsky Federal Research Medical Centre 18, Verkhne-Volzhskaya nab., Nizhny Novgorod, 603155, Russia Novgorod State Medical Academy 10/1, pl. Minina i Pozharskogo, Nizhny Novgorod, 603155, RussiaThe purpose of the study – assessment of the efficacy of local application of tranexamic acid in TKA and the choice of the optimal dosage. Materials and methods. 48 patients were included in open-prospective study and were randomized to one of four groups. In the first group tranexamic acid was used as intravenous bolus at the beginning of the operation at a dose of 15 mg/kg. Additionally, after the installation of the prosthetic components, the surgeon performed periarticular infiltration of soft tissue by tranexamic acid solution at a dose of 15 mg/kg. In the second group of patients tranexamic acid was used as 500 mg intravenous bolus before surgery, and 500 mg locally after installation of the prosthesis components. In the third group of patients received tranexamic acid once at the beginning of the operation at a dose of 15 mg/kg iv bolus. In the fourth group tranexam was used after surgery once at a dose of 10 mg/kg. Results. In the first group of patients were achieved statistically significant, 5-6 times, reduction of blood loss on drainage in comparison with other groups, where the volume of postoperative blood loss was not significantly different between groups. Also in the first group recorded the smallest decrease in hemoglobin at the 5th postoperative day compared to the third and fourth groups. Complications associated with the use of tranexamic acid were not revealed. Conclusion. The method of periarticular infiltration by tranexamic acid in combination with its intravenous use in knee joint replacement is an effective and safe method for reduction of post-operative blood loss.https://journal.rniito.org/jour/article/view/634tkablood losstranexamic acid |
| spellingShingle | E. V. Pshenitsyna V. I. Zagrekov E. E. Malyshev LOCAL APPLICATION OF TRANEXAMIC ACID IN KNEE REPLACEMENT Travmatologiâ i Ortopediâ Rossii tka blood loss tranexamic acid |
| title | LOCAL APPLICATION OF TRANEXAMIC ACID IN KNEE REPLACEMENT |
| title_full | LOCAL APPLICATION OF TRANEXAMIC ACID IN KNEE REPLACEMENT |
| title_fullStr | LOCAL APPLICATION OF TRANEXAMIC ACID IN KNEE REPLACEMENT |
| title_full_unstemmed | LOCAL APPLICATION OF TRANEXAMIC ACID IN KNEE REPLACEMENT |
| title_short | LOCAL APPLICATION OF TRANEXAMIC ACID IN KNEE REPLACEMENT |
| title_sort | local application of tranexamic acid in knee replacement |
| topic | tka blood loss tranexamic acid |
| url | https://journal.rniito.org/jour/article/view/634 |
| work_keys_str_mv | AT evpshenitsyna localapplicationoftranexamicacidinkneereplacement AT vizagrekov localapplicationoftranexamicacidinkneereplacement AT eemalyshev localapplicationoftranexamicacidinkneereplacement |