Persistence of Immunity in Adults after 1, 5 and 10 Years with Recombinant Hepatitis B Vaccine in Beijing in 2010–2020
The persistence of immunity after hepatitis B vaccination is still under investigation in adults. In Chaoyang District, Beijing, people who were aged ≥ 18 years and completely immunized with HBV vaccine according to the standard procedure (0–1–6 months) were enrolled. Three groups were set for 1 (Y1...
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MDPI AG
2022-01-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/2/181 |
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| author | Sijia Shen Shen Ge Zheng Zhang Jianxin Ma Yang Jiao Qian Li Yan Liang Shuming Li |
| author_facet | Sijia Shen Shen Ge Zheng Zhang Jianxin Ma Yang Jiao Qian Li Yan Liang Shuming Li |
| author_sort | Sijia Shen |
| collection | DOAJ |
| description | The persistence of immunity after hepatitis B vaccination is still under investigation in adults. In Chaoyang District, Beijing, people who were aged ≥ 18 years and completely immunized with HBV vaccine according to the standard procedure (0–1–6 months) were enrolled. Three groups were set for 1 (Y1), 5 (Y5) and 10 (Y10) years after the hepatitis B vaccination. The following data was collected and analyzed: antibody against hepatitis B virus surface antigen(anti-HBs) positive rates and geometric mean concentration (GMC) between the different compared groups through questionnaires and laboratory detection, including hepatitis B virus surface antigen (HBsAg), anti-HBs and antibody against hepatitis B virus core antigen(anti-HBc). All 600 subjects completed the questionnaires and serological tests. Among all subjects, the positive rates of HBsAg, anti-HBs and anti-HBc were 0, 70.5% (423/600) and 2.5% (15/600), respectively. The anti-HBs positive rates in Y1, Y5 and Y10 groups were 86.5% (173/200), 71.0% (142/200) and 54.0% (108/200) (χ<sup>2</sup> = 50.8, <i>p</i> < 0.001) and showed a linear decreasing trend year by year (trend χ<sup>2</sup> = 50.7, <i>p</i> < 0.001). The GMC in Y1, Y5 and Y10 groups were 296.6 mIU/mL, 51.6 mIU/mL and 25.5 mIU/mL (H = 64.8, <i>p</i> < 0.001), respectively. The anti-HBs positive rates and GMC decreased rapidly after the vaccination of adults against hepatitis B. Screening after 5–10 years and booster vaccination for the unprotected population is recommended. |
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| language | English |
| last_indexed | 2024-03-09T20:54:50Z |
| publishDate | 2022-01-01 |
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| series | Vaccines |
| spelling | doaj.art-c67c06ab65814b358e1bbf6d30e87cc52023-11-23T22:24:50ZengMDPI AGVaccines2076-393X2022-01-0110218110.3390/vaccines10020181Persistence of Immunity in Adults after 1, 5 and 10 Years with Recombinant Hepatitis B Vaccine in Beijing in 2010–2020Sijia Shen0Shen Ge1Zheng Zhang2Jianxin Ma3Yang Jiao4Qian Li5Yan Liang6Shuming Li7School of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaChaoyang District Center for Disease Prevention and Control of Beijing, Beijing 100020, ChinaChaoyang District Center for Disease Prevention and Control of Beijing, Beijing 100020, ChinaChaoyang District Center for Disease Prevention and Control of Beijing, Beijing 100020, ChinaChaoyang District Center for Disease Prevention and Control of Beijing, Beijing 100020, ChinaChaoyang District Center for Disease Prevention and Control of Beijing, Beijing 100020, ChinaChaoyang District Center for Disease Prevention and Control of Beijing, Beijing 100020, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaThe persistence of immunity after hepatitis B vaccination is still under investigation in adults. In Chaoyang District, Beijing, people who were aged ≥ 18 years and completely immunized with HBV vaccine according to the standard procedure (0–1–6 months) were enrolled. Three groups were set for 1 (Y1), 5 (Y5) and 10 (Y10) years after the hepatitis B vaccination. The following data was collected and analyzed: antibody against hepatitis B virus surface antigen(anti-HBs) positive rates and geometric mean concentration (GMC) between the different compared groups through questionnaires and laboratory detection, including hepatitis B virus surface antigen (HBsAg), anti-HBs and antibody against hepatitis B virus core antigen(anti-HBc). All 600 subjects completed the questionnaires and serological tests. Among all subjects, the positive rates of HBsAg, anti-HBs and anti-HBc were 0, 70.5% (423/600) and 2.5% (15/600), respectively. The anti-HBs positive rates in Y1, Y5 and Y10 groups were 86.5% (173/200), 71.0% (142/200) and 54.0% (108/200) (χ<sup>2</sup> = 50.8, <i>p</i> < 0.001) and showed a linear decreasing trend year by year (trend χ<sup>2</sup> = 50.7, <i>p</i> < 0.001). The GMC in Y1, Y5 and Y10 groups were 296.6 mIU/mL, 51.6 mIU/mL and 25.5 mIU/mL (H = 64.8, <i>p</i> < 0.001), respectively. The anti-HBs positive rates and GMC decreased rapidly after the vaccination of adults against hepatitis B. Screening after 5–10 years and booster vaccination for the unprotected population is recommended.https://www.mdpi.com/2076-393X/10/2/181hepatitis B vaccineadultimmune persistence |
| spellingShingle | Sijia Shen Shen Ge Zheng Zhang Jianxin Ma Yang Jiao Qian Li Yan Liang Shuming Li Persistence of Immunity in Adults after 1, 5 and 10 Years with Recombinant Hepatitis B Vaccine in Beijing in 2010–2020 Vaccines hepatitis B vaccine adult immune persistence |
| title | Persistence of Immunity in Adults after 1, 5 and 10 Years with Recombinant Hepatitis B Vaccine in Beijing in 2010–2020 |
| title_full | Persistence of Immunity in Adults after 1, 5 and 10 Years with Recombinant Hepatitis B Vaccine in Beijing in 2010–2020 |
| title_fullStr | Persistence of Immunity in Adults after 1, 5 and 10 Years with Recombinant Hepatitis B Vaccine in Beijing in 2010–2020 |
| title_full_unstemmed | Persistence of Immunity in Adults after 1, 5 and 10 Years with Recombinant Hepatitis B Vaccine in Beijing in 2010–2020 |
| title_short | Persistence of Immunity in Adults after 1, 5 and 10 Years with Recombinant Hepatitis B Vaccine in Beijing in 2010–2020 |
| title_sort | persistence of immunity in adults after 1 5 and 10 years with recombinant hepatitis b vaccine in beijing in 2010 2020 |
| topic | hepatitis B vaccine adult immune persistence |
| url | https://www.mdpi.com/2076-393X/10/2/181 |
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