Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis

Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis

Pressure overload in patients with aortic stenosis (AS) induces an adverse remodeling of the left ventricle (LV) in a sex-specific manner. We assessed whether a sex-specific miR-29b dysregulation underlies this sex-biased remodeling pattern, as has been described in liver fibrosis. We studied mice w...

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Bibliographic Details
Main Authors: Raquel García, Ana B. Salido-Medina, Aritz Gil, David Merino, Jenny Gómez, Ana V. Villar, Francisco González-Vílchez, María A. Hurlé, J. Francisco Nistal
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
miR-29b
aortic stenosis patients
pressure overload
cardiac remodeling
sex differences
Online Access:https://www.mdpi.com/2073-4409/9/4/833

Internet

https://www.mdpi.com/2073-4409/9/4/833

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