Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugs
Complexes of transition metals [Co(II), Cd(II) and Mo(0)] with a new enaminone (PA) 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one were synthesized and afterwards characterized by 1H NMR, 13C NMR, FAB-MS, UV–Vis, ICP-OES, TGA and FTIR. The spectroscopic and conductance data suggested that the li...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535221006559 |
| _version_ | 1819278703142633472 |
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| author | Rahila Huma Tariq Mahmud Sana Javaid Awan Muhammad Ashraf Shafi Ullah Khan Humaira Rasheed Syeda Marium Hasany Amna Yousaf |
| author_facet | Rahila Huma Tariq Mahmud Sana Javaid Awan Muhammad Ashraf Shafi Ullah Khan Humaira Rasheed Syeda Marium Hasany Amna Yousaf |
| author_sort | Rahila Huma |
| collection | DOAJ |
| description | Complexes of transition metals [Co(II), Cd(II) and Mo(0)] with a new enaminone (PA) 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one were synthesized and afterwards characterized by 1H NMR, 13C NMR, FAB-MS, UV–Vis, ICP-OES, TGA and FTIR. The spectroscopic and conductance data suggested that the ligand (PA) is attached to the metal ions in bidentate, neutral form through the nitrogen atom of amino group and the oxygen of carbonyl group. Metal complexes displayed octahedral geometries. In vitro urease inhibition and cytotoxic activities of all the compounds were evaluated. Results revealed that Co(II) complex (PA-Co) was even more significant than the reference drug thiourea. Analysis of the cytotoxicity indicated that, the Co(II) complex has more cytotoxic effect than enaminone ligand and other complexes when assessed on the human cancer cell lines MCF-7.Molecular docking simulation was also performed to find out the putative binding mode within the target protein. |
| first_indexed | 2024-12-24T00:16:13Z |
| format | Article |
| id | doaj.art-c67f1c43348141129875a2450eebcc4f |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-24T00:16:13Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-c67f1c43348141129875a2450eebcc4f2022-12-21T17:24:44ZengElsevierArabian Journal of Chemistry1878-53522022-03-01153103640Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugsRahila Huma0Tariq Mahmud1Sana Javaid Awan2Muhammad Ashraf3Shafi Ullah Khan4Humaira Rasheed5Syeda Marium Hasany6Amna Yousaf7Kinnaird College for Women, 93-Jail Road, Lahore 54000, Pakistan; Corresponding author.School of Chemistry, University of the Punjab, Lahore 54590, PakistanKinnaird College for Women, 93-Jail Road, Lahore 54000, PakistanDepartment of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, PakistanSchool of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia; Department of Pharmacy, Abasyn University, Peshawar, PakistanKinnaird College for Women, 93-Jail Road, Lahore 54000, PakistanKinnaird College for Women, 93-Jail Road, Lahore 54000, PakistanKinnaird College for Women, 93-Jail Road, Lahore 54000, PakistanComplexes of transition metals [Co(II), Cd(II) and Mo(0)] with a new enaminone (PA) 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one were synthesized and afterwards characterized by 1H NMR, 13C NMR, FAB-MS, UV–Vis, ICP-OES, TGA and FTIR. The spectroscopic and conductance data suggested that the ligand (PA) is attached to the metal ions in bidentate, neutral form through the nitrogen atom of amino group and the oxygen of carbonyl group. Metal complexes displayed octahedral geometries. In vitro urease inhibition and cytotoxic activities of all the compounds were evaluated. Results revealed that Co(II) complex (PA-Co) was even more significant than the reference drug thiourea. Analysis of the cytotoxicity indicated that, the Co(II) complex has more cytotoxic effect than enaminone ligand and other complexes when assessed on the human cancer cell lines MCF-7.Molecular docking simulation was also performed to find out the putative binding mode within the target protein.http://www.sciencedirect.com/science/article/pii/S1878535221006559Anti-urease activityCytotoxicityEnaminoneMetal complexes |
| spellingShingle | Rahila Huma Tariq Mahmud Sana Javaid Awan Muhammad Ashraf Shafi Ullah Khan Humaira Rasheed Syeda Marium Hasany Amna Yousaf Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugs Arabian Journal of Chemistry Anti-urease activity Cytotoxicity Enaminone Metal complexes |
| title | Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugs |
| title_full | Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugs |
| title_fullStr | Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugs |
| title_full_unstemmed | Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugs |
| title_short | Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugs |
| title_sort | thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3 chloro 4 4 methoxyphenyl amino pent 3 en 2 one and their investigation as anti urease and cytotoxic potential drugs |
| topic | Anti-urease activity Cytotoxicity Enaminone Metal complexes |
| url | http://www.sciencedirect.com/science/article/pii/S1878535221006559 |
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