Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease

Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease

Variants in the GBA1 and LRRK2 genes are the most common genetic risk factors associated with Parkinson disease (PD). Both genes are associated with lysosomal and autophagic pathways, with the GBA1 gene encoding for the lysosomal enzyme, glucocerebrosidase (GCase) and the LRRK2 gene encoding for the...

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Bibliographic Details
Main Authors: Laura J. Smith, Chiao-Yin Lee, Elisa Menozzi, Anthony H. V. Schapira
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Neurology
Subjects:
Parkinson's disease
glucocerebrosidase
LRRK2
GBA1
lysosome
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.971252/full

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