Butyrate and obesity: Current research status and future prospect
Over the past few decades, increasing prevalence of obesity caused an enormous medical, social, and economic burden. As the sixth most important risk factor contributing to the overall burden of disease worldwide, obesity not only directly harms the human body, but also leads to many chronic disease...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1098881/full |
| _version_ | 1797895431337803776 |
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| author | Ke Peng Ke Peng Wenjie Dong Wenjie Dong Taimin Luo Hui Tang Hui Tang Wanlong Zhu Wanlong Zhu Yilan Huang Yilan Huang Xuping Yang Xuping Yang |
| author_facet | Ke Peng Ke Peng Wenjie Dong Wenjie Dong Taimin Luo Hui Tang Hui Tang Wanlong Zhu Wanlong Zhu Yilan Huang Yilan Huang Xuping Yang Xuping Yang |
| author_sort | Ke Peng |
| collection | DOAJ |
| description | Over the past few decades, increasing prevalence of obesity caused an enormous medical, social, and economic burden. As the sixth most important risk factor contributing to the overall burden of disease worldwide, obesity not only directly harms the human body, but also leads to many chronic diseases such as diabetes, cardiovascular diseases (CVD), nonalcoholic fatty liver disease (NAFLD), and mental illness. Weight loss is still one of the most effective strategies against obesity and related disorders. Recently, the link between intestinal microflora and metabolic health has been constantly established. Butyrate, a four-carbon short-chain fatty acid, is a major metabolite of the gut microbiota that has many beneficial effects on metabolic health. The anti-obesity activity of butyrate has been demonstrated, but its mechanisms of action have not been fully described. This review summarizes current knowledge of butyrate, including its production, absorption, distribution, metabolism, and the effect and mechanisms involved in weight loss and obesity-related diseases. The aim was to contribute to and advance our understanding of butyrate and its role in obesity. Further exploration of butyrate and its pathway may help to identify new anti-obesity. |
| first_indexed | 2024-04-10T07:25:31Z |
| format | Article |
| id | doaj.art-c67fa27466364a8d8f90f6bfdf36b5af |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T07:25:31Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-c67fa27466364a8d8f90f6bfdf36b5af2023-02-24T07:45:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.10988811098881Butyrate and obesity: Current research status and future prospectKe Peng0Ke Peng1Wenjie Dong2Wenjie Dong3Taimin Luo4Hui Tang5Hui Tang6Wanlong Zhu7Wanlong Zhu8Yilan Huang9Yilan Huang10Xuping Yang11Xuping Yang12Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, Chengdu Seventh People’s Hospital, Chengdu, Sichuan, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, ChinaOver the past few decades, increasing prevalence of obesity caused an enormous medical, social, and economic burden. As the sixth most important risk factor contributing to the overall burden of disease worldwide, obesity not only directly harms the human body, but also leads to many chronic diseases such as diabetes, cardiovascular diseases (CVD), nonalcoholic fatty liver disease (NAFLD), and mental illness. Weight loss is still one of the most effective strategies against obesity and related disorders. Recently, the link between intestinal microflora and metabolic health has been constantly established. Butyrate, a four-carbon short-chain fatty acid, is a major metabolite of the gut microbiota that has many beneficial effects on metabolic health. The anti-obesity activity of butyrate has been demonstrated, but its mechanisms of action have not been fully described. This review summarizes current knowledge of butyrate, including its production, absorption, distribution, metabolism, and the effect and mechanisms involved in weight loss and obesity-related diseases. The aim was to contribute to and advance our understanding of butyrate and its role in obesity. Further exploration of butyrate and its pathway may help to identify new anti-obesity.https://www.frontiersin.org/articles/10.3389/fendo.2023.1098881/fullbutyrateSCFAsgut microbiotaobesitymetabolic disease |
| spellingShingle | Ke Peng Ke Peng Wenjie Dong Wenjie Dong Taimin Luo Hui Tang Hui Tang Wanlong Zhu Wanlong Zhu Yilan Huang Yilan Huang Xuping Yang Xuping Yang Butyrate and obesity: Current research status and future prospect Frontiers in Endocrinology butyrate SCFAs gut microbiota obesity metabolic disease |
| title | Butyrate and obesity: Current research status and future prospect |
| title_full | Butyrate and obesity: Current research status and future prospect |
| title_fullStr | Butyrate and obesity: Current research status and future prospect |
| title_full_unstemmed | Butyrate and obesity: Current research status and future prospect |
| title_short | Butyrate and obesity: Current research status and future prospect |
| title_sort | butyrate and obesity current research status and future prospect |
| topic | butyrate SCFAs gut microbiota obesity metabolic disease |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1098881/full |
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