Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment

Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment

Abstract Background Associations of low lung function with features of poor cardio-metabolic health have been reported. It is, however, unclear whether these co-morbidities reflect causal associations, shared genetic heritability or are confounded by environmental factors. Methods We performed three...

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Bibliographic Details
Main Authors: Matthias Wielscher, Andre F. S. Amaral, Diana van der Plaat, Louise V. Wain, Sylvain Sebert, David Mosen-Ansorena, Juha Auvinen, Karl-Heinz Herzig, Abbas Dehghan, Debbie L. Jarvis, Marjo-Riitta Jarvelin
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Genome Medicine
Subjects:
Mendelian randomisation
Metabolic syndrome
Obesity
Chronic obstructive pulmonary disease
UK Biobank
Online Access:https://doi.org/10.1186/s13073-021-00914-x

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