Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review

Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review

Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategie...

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Bibliographic Details
Main Authors: Tara Talaie, MD, MS, Laura DiChiacchio, MD, PhD, Nikhil K. Prasad, MB, ChB, Chetan Pasrija, MD, Walker Julliard, MD, David J. Kaczorowski, MD, Yunge Zhao, MD, PhD, Christine L. Lau, MD
Format: Article
Language:English
Published: Wolters Kluwer 2021-02-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001104
Description
Summary:Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategies are still needed to improve outcomes after lung transplantation. In this review, we discuss the underlying mechanisms of transplanted LIRI, potential modifiable targets, current practices, and areas of ongoing investigation to reduce LIRI and primary graft dysfunction in lung transplant recipients.
ISSN:2373-8731

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