Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review
Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategie...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2021-02-01
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| Series: | Transplantation Direct |
| Online Access: | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001104 |
| _version_ | 1819054499963076608 |
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| author | Tara Talaie, MD, MS Laura DiChiacchio, MD, PhD Nikhil K. Prasad, MB, ChB Chetan Pasrija, MD Walker Julliard, MD David J. Kaczorowski, MD Yunge Zhao, MD, PhD Christine L. Lau, MD |
| author_facet | Tara Talaie, MD, MS Laura DiChiacchio, MD, PhD Nikhil K. Prasad, MB, ChB Chetan Pasrija, MD Walker Julliard, MD David J. Kaczorowski, MD Yunge Zhao, MD, PhD Christine L. Lau, MD |
| author_sort | Tara Talaie, MD, MS |
| collection | DOAJ |
| description | Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategies are still needed to improve outcomes after lung transplantation. In this review, we discuss the underlying mechanisms of transplanted LIRI, potential modifiable targets, current practices, and areas of ongoing investigation to reduce LIRI and primary graft dysfunction in lung transplant recipients. |
| first_indexed | 2024-12-21T12:52:36Z |
| format | Article |
| id | doaj.art-c680b57890f448e7804b295bf3787442 |
| institution | Directory Open Access Journal |
| issn | 2373-8731 |
| language | English |
| last_indexed | 2024-12-21T12:52:36Z |
| publishDate | 2021-02-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Transplantation Direct |
| spelling | doaj.art-c680b57890f448e7804b295bf37874422022-12-21T19:03:26ZengWolters KluwerTransplantation Direct2373-87312021-02-0172e65210.1097/TXD.0000000000001104202102000-00005Ischemia-reperfusion Injury in the Transplanted Lung: A Literature ReviewTara Talaie, MD, MS0Laura DiChiacchio, MD, PhD1Nikhil K. Prasad, MB, ChB2Chetan Pasrija, MD3Walker Julliard, MD4David J. Kaczorowski, MD5Yunge Zhao, MD, PhD6Christine L. Lau, MD71 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.2 Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA.1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategies are still needed to improve outcomes after lung transplantation. In this review, we discuss the underlying mechanisms of transplanted LIRI, potential modifiable targets, current practices, and areas of ongoing investigation to reduce LIRI and primary graft dysfunction in lung transplant recipients.http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001104 |
| spellingShingle | Tara Talaie, MD, MS Laura DiChiacchio, MD, PhD Nikhil K. Prasad, MB, ChB Chetan Pasrija, MD Walker Julliard, MD David J. Kaczorowski, MD Yunge Zhao, MD, PhD Christine L. Lau, MD Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review Transplantation Direct |
| title | Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review |
| title_full | Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review |
| title_fullStr | Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review |
| title_full_unstemmed | Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review |
| title_short | Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review |
| title_sort | ischemia reperfusion injury in the transplanted lung a literature review |
| url | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001104 |
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