Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact
The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically distinct and partially independent calcium (Ca<sup>2+</sup>) signaling microdomain, with its own Ca<sup>2+</sup>-regulatory mechanisms and important effects on cardiac gene expression. In thi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/960 |
| _version_ | 1797613297799790592 |
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| author | Mara Kiessling Nataša Djalinac Julia Voglhuber Senka Ljubojevic-Holzer |
| author_facet | Mara Kiessling Nataša Djalinac Julia Voglhuber Senka Ljubojevic-Holzer |
| author_sort | Mara Kiessling |
| collection | DOAJ |
| description | The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically distinct and partially independent calcium (Ca<sup>2+</sup>) signaling microdomain, with its own Ca<sup>2+</sup>-regulatory mechanisms and important effects on cardiac gene expression. In this review, we (1) provide a comprehensive overview of the current state of research on the dynamics and regulation of nuclear Ca<sup>2+</sup> signaling in cardiomyocytes, (2) address the role of nuclear Ca<sup>2+</sup> in the development and progression of cardiac pathologies, such as heart failure and atrial fibrillation, and (3) discuss novel aspects of experimental methods to investigate nuclear Ca<sup>2+</sup> handling and its downstream effects in the heart. Finally, we highlight current challenges and limitations and recommend future directions for addressing key open questions. |
| first_indexed | 2024-03-11T06:53:53Z |
| format | Article |
| id | doaj.art-c683cc35d6ca417296af98bea0fee550 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:53Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c683cc35d6ca417296af98bea0fee5502023-11-17T09:48:08ZengMDPI AGBiomedicines2227-90592023-03-0111396010.3390/biomedicines11030960Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big ImpactMara Kiessling0Nataša Djalinac1Julia Voglhuber2Senka Ljubojevic-Holzer3Department of Cardiology, Medical University of Graz, 8036 Graz, AustriaDepartment of Biology, University of Padua, 35122 Padova, ItalyDepartment of Cardiology, Medical University of Graz, 8036 Graz, AustriaDepartment of Cardiology, Medical University of Graz, 8036 Graz, AustriaThe nucleus of a cardiomyocyte has been increasingly recognized as a morphologically distinct and partially independent calcium (Ca<sup>2+</sup>) signaling microdomain, with its own Ca<sup>2+</sup>-regulatory mechanisms and important effects on cardiac gene expression. In this review, we (1) provide a comprehensive overview of the current state of research on the dynamics and regulation of nuclear Ca<sup>2+</sup> signaling in cardiomyocytes, (2) address the role of nuclear Ca<sup>2+</sup> in the development and progression of cardiac pathologies, such as heart failure and atrial fibrillation, and (3) discuss novel aspects of experimental methods to investigate nuclear Ca<sup>2+</sup> handling and its downstream effects in the heart. Finally, we highlight current challenges and limitations and recommend future directions for addressing key open questions.https://www.mdpi.com/2227-9059/11/3/960nuclear calciumexcitation-contraction couplingexcitation-transcription couplingcardiac remodelingheart failureatrial fibrillation |
| spellingShingle | Mara Kiessling Nataša Djalinac Julia Voglhuber Senka Ljubojevic-Holzer Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact Biomedicines nuclear calcium excitation-contraction coupling excitation-transcription coupling cardiac remodeling heart failure atrial fibrillation |
| title | Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact |
| title_full | Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact |
| title_fullStr | Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact |
| title_full_unstemmed | Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact |
| title_short | Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact |
| title_sort | nuclear calcium in cardiac patho physiology small compartment big impact |
| topic | nuclear calcium excitation-contraction coupling excitation-transcription coupling cardiac remodeling heart failure atrial fibrillation |
| url | https://www.mdpi.com/2227-9059/11/3/960 |
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