The effects of microglia on tauopathy progression can be quantified using Nexopathy in silico (Nexis) models

Abstract The prion-like transsynaptic propagation of misfolded tau along the brain’s connectome has previously been modeled using connectome-based network diffusion models. In addition to the connectome, interactions between the general neurological “milieu” in the neurodegenerative brain and protei...

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Bibliographic Details
Main Authors: Chaitali Anand, Pedro D. Maia, Justin Torok, Christopher Mezias, Ashish Raj
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25131-3