Study of Physico-Chemical Properties and Morphology of Phospholipid Composition of Indomethacin
Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of cyclooxygenase-2, an enzyme involved in the formation of anti-inflammatory prostaglandin PGE2, are the most common treatment for chronic inflammatory diseases, such as, for example, arthritis. One of the most commonly used drugs of this cl...
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MDPI AG
2022-07-01
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| Series: | Nanomaterials |
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| author | Elena G. Tikhonova Yulia A. Tereshkina Lyubov V. Kostryukova Yulia Yu. Khudoklinova Maxim A. Sanzhakov Anna O. Tamarovskaya Oleksandr I. Ivankov Mikhail A. Kiselev |
| author_facet | Elena G. Tikhonova Yulia A. Tereshkina Lyubov V. Kostryukova Yulia Yu. Khudoklinova Maxim A. Sanzhakov Anna O. Tamarovskaya Oleksandr I. Ivankov Mikhail A. Kiselev |
| author_sort | Elena G. Tikhonova |
| collection | DOAJ |
| description | Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of cyclooxygenase-2, an enzyme involved in the formation of anti-inflammatory prostaglandin PGE2, are the most common treatment for chronic inflammatory diseases, such as, for example, arthritis. One of the most commonly used drugs of this class is indomethacin, a derivative of indolylacetic acid. In this work, we studied the physicochemical properties of the phospholipid composition of indomethacin obtained earlier (codenamed “Indolip”) and the effect of freeze drying on its parameters. It was shown that the properties such as particle size, light transmission, phospholipid oxidation index did not change significantly, which indicated the stability of the drug after lyophilization. Measurement of the spectra of small-angle neutron scattering has shown that morphologically, Indolip is a vesicle whose radius is five times greater than the value of the bilayer thickness. |
| first_indexed | 2024-03-09T10:06:49Z |
| format | Article |
| id | doaj.art-c685b013fc094ebf919771bc280a3f92 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T10:06:49Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-c685b013fc094ebf919771bc280a3f922023-12-01T23:04:13ZengMDPI AGNanomaterials2079-49912022-07-011215255310.3390/nano12152553Study of Physico-Chemical Properties and Morphology of Phospholipid Composition of IndomethacinElena G. Tikhonova0Yulia A. Tereshkina1Lyubov V. Kostryukova2Yulia Yu. Khudoklinova3Maxim A. Sanzhakov4Anna O. Tamarovskaya5Oleksandr I. Ivankov6Mikhail A. Kiselev7Institute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, RussiaInstitute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, RussiaInstitute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, RussiaInstitute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, RussiaInstitute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, RussiaJoint Institute for Nuclear Research, 6 Joliot-Curie St., 141980 Dubna, RussiaJoint Institute for Nuclear Research, 6 Joliot-Curie St., 141980 Dubna, RussiaJoint Institute for Nuclear Research, 6 Joliot-Curie St., 141980 Dubna, RussiaNonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of cyclooxygenase-2, an enzyme involved in the formation of anti-inflammatory prostaglandin PGE2, are the most common treatment for chronic inflammatory diseases, such as, for example, arthritis. One of the most commonly used drugs of this class is indomethacin, a derivative of indolylacetic acid. In this work, we studied the physicochemical properties of the phospholipid composition of indomethacin obtained earlier (codenamed “Indolip”) and the effect of freeze drying on its parameters. It was shown that the properties such as particle size, light transmission, phospholipid oxidation index did not change significantly, which indicated the stability of the drug after lyophilization. Measurement of the spectra of small-angle neutron scattering has shown that morphologically, Indolip is a vesicle whose radius is five times greater than the value of the bilayer thickness.https://www.mdpi.com/2079-4991/12/15/2553phospholipid nanoparticlesIndolipvesiclessmall-angle neutron scatteringlyophilizationphysico-chemical properties |
| spellingShingle | Elena G. Tikhonova Yulia A. Tereshkina Lyubov V. Kostryukova Yulia Yu. Khudoklinova Maxim A. Sanzhakov Anna O. Tamarovskaya Oleksandr I. Ivankov Mikhail A. Kiselev Study of Physico-Chemical Properties and Morphology of Phospholipid Composition of Indomethacin Nanomaterials phospholipid nanoparticles Indolip vesicles small-angle neutron scattering lyophilization physico-chemical properties |
| title | Study of Physico-Chemical Properties and Morphology of Phospholipid Composition of Indomethacin |
| title_full | Study of Physico-Chemical Properties and Morphology of Phospholipid Composition of Indomethacin |
| title_fullStr | Study of Physico-Chemical Properties and Morphology of Phospholipid Composition of Indomethacin |
| title_full_unstemmed | Study of Physico-Chemical Properties and Morphology of Phospholipid Composition of Indomethacin |
| title_short | Study of Physico-Chemical Properties and Morphology of Phospholipid Composition of Indomethacin |
| title_sort | study of physico chemical properties and morphology of phospholipid composition of indomethacin |
| topic | phospholipid nanoparticles Indolip vesicles small-angle neutron scattering lyophilization physico-chemical properties |
| url | https://www.mdpi.com/2079-4991/12/15/2553 |
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