Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation
Reducing inflammation by diet is a major goal for prevention or lowering symptoms of a variety of diseases, such as auto-immune reactions and cancers. Natural polysaccharides are increasingly gaining attention due to their potential immunomodulating capacity. Structures of those molecules are highly...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Structural Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665928X23000181 |
| _version_ | 1797397573360680960 |
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| author | Lucas de Freitas Pedrosa Paul de Vos João Paulo Fabi |
| author_facet | Lucas de Freitas Pedrosa Paul de Vos João Paulo Fabi |
| author_sort | Lucas de Freitas Pedrosa |
| collection | DOAJ |
| description | Reducing inflammation by diet is a major goal for prevention or lowering symptoms of a variety of diseases, such as auto-immune reactions and cancers. Natural polysaccharides are increasingly gaining attention due to their potential immunomodulating capacity. Structures of those molecules are highly important for their effects on the innate immune system, cytokine production and secretion, and enzymes in immune cells. Such polysaccharides include β-glucans, pectins, fucoidans, and fructans. To better understand the potential of these immunomodulatory molecules, it is crucial to enhance dedicated research in the area. A bibliometric analysis was performed to set a starting observation point. Major pillars of inflammation, such as pattern recognition receptors (PRRs), enzymatic production of inflammatory molecules, and involvement in specific pathways such as Nuclear-factor kappa-B (NF-kB), involved in cell transcription, survival, and cytokine production, and mitogen-activated protein kinase (MAPK), a regulator of genetic expression, mitosis, and cell differentiation. Therefore, the outcomes from polysaccharide applications in those scenarios are discussed. |
| first_indexed | 2024-03-09T01:12:02Z |
| format | Article |
| id | doaj.art-c687431a42994a16960695aaee3ea55b |
| institution | Directory Open Access Journal |
| issn | 2665-928X |
| language | English |
| last_indexed | 2024-03-09T01:12:02Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Structural Biology |
| spelling | doaj.art-c687431a42994a16960695aaee3ea55b2023-12-11T04:17:06ZengElsevierCurrent Research in Structural Biology2665-928X2023-01-016100112Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammationLucas de Freitas Pedrosa0Paul de Vos1João Paulo Fabi2Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen, the NetherlandsDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen, the NetherlandsDepartment of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil; Food and Nutrition Research Center (NAPAN), University of São Paulo, São Paulo, SP, Brazil; Food Research Center (ForC), CEPID-FAPESP (Research, Innovation and Dissemination Centers, São Paulo Research Foundation), São Paulo, SP, Brazil; Corresponding author. Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.Reducing inflammation by diet is a major goal for prevention or lowering symptoms of a variety of diseases, such as auto-immune reactions and cancers. Natural polysaccharides are increasingly gaining attention due to their potential immunomodulating capacity. Structures of those molecules are highly important for their effects on the innate immune system, cytokine production and secretion, and enzymes in immune cells. Such polysaccharides include β-glucans, pectins, fucoidans, and fructans. To better understand the potential of these immunomodulatory molecules, it is crucial to enhance dedicated research in the area. A bibliometric analysis was performed to set a starting observation point. Major pillars of inflammation, such as pattern recognition receptors (PRRs), enzymatic production of inflammatory molecules, and involvement in specific pathways such as Nuclear-factor kappa-B (NF-kB), involved in cell transcription, survival, and cytokine production, and mitogen-activated protein kinase (MAPK), a regulator of genetic expression, mitosis, and cell differentiation. Therefore, the outcomes from polysaccharide applications in those scenarios are discussed.http://www.sciencedirect.com/science/article/pii/S2665928X23000181InflammationPolysaccharidesPattern recognition receptors |
| spellingShingle | Lucas de Freitas Pedrosa Paul de Vos João Paulo Fabi Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation Current Research in Structural Biology Inflammation Polysaccharides Pattern recognition receptors |
| title | Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation |
| title_full | Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation |
| title_fullStr | Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation |
| title_full_unstemmed | Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation |
| title_short | Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation |
| title_sort | nature s soothing solution harnessing the potential of food derived polysaccharides to control inflammation |
| topic | Inflammation Polysaccharides Pattern recognition receptors |
| url | http://www.sciencedirect.com/science/article/pii/S2665928X23000181 |
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