Health-related quality of life in glioma patients in China
<p>Abstract</p> <p>Background</p> <p>Health-related quality of life (HRQOL) has been increasingly emphasized in cancer patients. There are no reports comparing baseline HRQOL of different subgroups of glioma patients prior to surgery.</p> <p>Methods</p>...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-06-01
|
| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/10/305 |
| _version_ | 1818682502628245504 |
|---|---|
| author | Lin Hong Zhang Jian-ning Liu Wei-ping Zhang Yong-qiang Lin Wei Zhang Xiang Liu Bo-lin Cheng Jin-xiang Wang Rui Yin Hong |
| author_facet | Lin Hong Zhang Jian-ning Liu Wei-ping Zhang Yong-qiang Lin Wei Zhang Xiang Liu Bo-lin Cheng Jin-xiang Wang Rui Yin Hong |
| author_sort | Lin Hong |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Health-related quality of life (HRQOL) has been increasingly emphasized in cancer patients. There are no reports comparing baseline HRQOL of different subgroups of glioma patients prior to surgery.</p> <p>Methods</p> <p>HRQOL assessments by the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30, version 3.0), the Mini-Mental State Examination and Karnofsky Performance Status were obtained from glioma patients prior to surgery.</p> <p>Results</p> <p>Ninety-two pathologically confirmed glioma patients were recruited. There were 84.8% patients with emotional impairment, 75% with social and cognitive impairment, 70.7% with physical impairment, and 50% with role impairment. Eighty-two percent of patients reported fatigue symptoms, 72.8% reported pain, 50% reported appetite loss, 39.1% reported insomnia, and 36.9% reported nausea/vomiting, whereas other symptoms (dyspnea, diarrhea, constipation) in the QLQ-C30 were reported by fewer than 30% of patients. Fatigue and pain symptoms and all "functioning" scales were strongly correlated with global health status/quality of life (QoL). Fatigue was strongly related to all functioning scales, pain, appetite loss, and global health status/QoL. No difference in baseline HRQOL prior to surgery was reported between females and males, among different lesion locations, or between normal- and abnormal-cognition subgroups of glioma patients. Age, KPS, WHO grade, and tumor recurrence significantly affected HRQOL in glioma patients.</p> <p>Conclusions</p> <p>These data provided the baseline HRQOL in glioma patients prior to surgery in China. Most pre-surgery glioma patients indicated emotional, social, cognitive, physical, and role impairment. Fatigue, pain, appetite loss, insomnia, and nausea/vomiting were common in these patients. The fatigue and pain symptoms and all types of functioning strongly affected global health status/QoL. Old age, worse performance status, WHO grade IV and tumor recurrence had deleterious effects on HRQOL.</p> |
| first_indexed | 2024-12-17T10:19:52Z |
| format | Article |
| id | doaj.art-c68878d3cdff48f8904c462b178647c4 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-17T10:19:52Z |
| publishDate | 2010-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-c68878d3cdff48f8904c462b178647c42022-12-21T21:52:50ZengBMCBMC Cancer1471-24072010-06-0110130510.1186/1471-2407-10-305Health-related quality of life in glioma patients in ChinaLin HongZhang Jian-ningLiu Wei-pingZhang Yong-qiangLin WeiZhang XiangLiu Bo-linCheng Jin-xiangWang RuiYin Hong<p>Abstract</p> <p>Background</p> <p>Health-related quality of life (HRQOL) has been increasingly emphasized in cancer patients. There are no reports comparing baseline HRQOL of different subgroups of glioma patients prior to surgery.</p> <p>Methods</p> <p>HRQOL assessments by the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30, version 3.0), the Mini-Mental State Examination and Karnofsky Performance Status were obtained from glioma patients prior to surgery.</p> <p>Results</p> <p>Ninety-two pathologically confirmed glioma patients were recruited. There were 84.8% patients with emotional impairment, 75% with social and cognitive impairment, 70.7% with physical impairment, and 50% with role impairment. Eighty-two percent of patients reported fatigue symptoms, 72.8% reported pain, 50% reported appetite loss, 39.1% reported insomnia, and 36.9% reported nausea/vomiting, whereas other symptoms (dyspnea, diarrhea, constipation) in the QLQ-C30 were reported by fewer than 30% of patients. Fatigue and pain symptoms and all "functioning" scales were strongly correlated with global health status/quality of life (QoL). Fatigue was strongly related to all functioning scales, pain, appetite loss, and global health status/QoL. No difference in baseline HRQOL prior to surgery was reported between females and males, among different lesion locations, or between normal- and abnormal-cognition subgroups of glioma patients. Age, KPS, WHO grade, and tumor recurrence significantly affected HRQOL in glioma patients.</p> <p>Conclusions</p> <p>These data provided the baseline HRQOL in glioma patients prior to surgery in China. Most pre-surgery glioma patients indicated emotional, social, cognitive, physical, and role impairment. Fatigue, pain, appetite loss, insomnia, and nausea/vomiting were common in these patients. The fatigue and pain symptoms and all types of functioning strongly affected global health status/QoL. Old age, worse performance status, WHO grade IV and tumor recurrence had deleterious effects on HRQOL.</p>http://www.biomedcentral.com/1471-2407/10/305 |
| spellingShingle | Lin Hong Zhang Jian-ning Liu Wei-ping Zhang Yong-qiang Lin Wei Zhang Xiang Liu Bo-lin Cheng Jin-xiang Wang Rui Yin Hong Health-related quality of life in glioma patients in China BMC Cancer |
| title | Health-related quality of life in glioma patients in China |
| title_full | Health-related quality of life in glioma patients in China |
| title_fullStr | Health-related quality of life in glioma patients in China |
| title_full_unstemmed | Health-related quality of life in glioma patients in China |
| title_short | Health-related quality of life in glioma patients in China |
| title_sort | health related quality of life in glioma patients in china |
| url | http://www.biomedcentral.com/1471-2407/10/305 |
| work_keys_str_mv | AT linhong healthrelatedqualityoflifeingliomapatientsinchina AT zhangjianning healthrelatedqualityoflifeingliomapatientsinchina AT liuweiping healthrelatedqualityoflifeingliomapatientsinchina AT zhangyongqiang healthrelatedqualityoflifeingliomapatientsinchina AT linwei healthrelatedqualityoflifeingliomapatientsinchina AT zhangxiang healthrelatedqualityoflifeingliomapatientsinchina AT liubolin healthrelatedqualityoflifeingliomapatientsinchina AT chengjinxiang healthrelatedqualityoflifeingliomapatientsinchina AT wangrui healthrelatedqualityoflifeingliomapatientsinchina AT yinhong healthrelatedqualityoflifeingliomapatientsinchina |