A Pragmatic Perspective of the Antibacterial Properties of Metal-Based Nanoparticles
A consideration of the antibacterial efficacy of metal-based nanoparticles, from the point of view of their physicochemical properties, suggests that such efficacy arises from the protein coronas that form around them, and that the contents of the coronas depend on the chemical groups found on the n...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/11/12/3214 |
| _version_ | 1797502075136901120 |
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| author | Edward Sacher Arthur Yelon |
| author_facet | Edward Sacher Arthur Yelon |
| author_sort | Edward Sacher |
| collection | DOAJ |
| description | A consideration of the antibacterial efficacy of metal-based nanoparticles, from the point of view of their physicochemical properties, suggests that such efficacy arises from the protein coronas that form around them, and that the contents of the coronas depend on the chemical groups found on the nanoparticle surfaces. We offer a new perspective and new insights, making use of our earlier observations of the physicochemical properties of nanoparticle surfaces, to propose that the nanoparticle serves as a mediator for the formation and activation of the protein corona, which attacks the bacterium. That is, the nanoparticle enhances the body’s natural defenses, using proteins present in body fluids. |
| first_indexed | 2024-03-10T03:27:40Z |
| format | Article |
| id | doaj.art-c6891b557bdc46dcbb71549fd075f806 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:27:40Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-c6891b557bdc46dcbb71549fd075f8062023-11-23T09:49:28ZengMDPI AGNanomaterials2079-49912021-11-011112321410.3390/nano11123214A Pragmatic Perspective of the Antibacterial Properties of Metal-Based NanoparticlesEdward Sacher0Arthur Yelon1Département de Génie Physique, Polytechnique Montréal, CP 6079, Succursale Centre-Ville, Montréal, QC H3C 3A7, CanadaDépartement de Génie Physique, Polytechnique Montréal, CP 6079, Succursale Centre-Ville, Montréal, QC H3C 3A7, CanadaA consideration of the antibacterial efficacy of metal-based nanoparticles, from the point of view of their physicochemical properties, suggests that such efficacy arises from the protein coronas that form around them, and that the contents of the coronas depend on the chemical groups found on the nanoparticle surfaces. We offer a new perspective and new insights, making use of our earlier observations of the physicochemical properties of nanoparticle surfaces, to propose that the nanoparticle serves as a mediator for the formation and activation of the protein corona, which attacks the bacterium. That is, the nanoparticle enhances the body’s natural defenses, using proteins present in body fluids.https://www.mdpi.com/2079-4991/11/12/3214antibacterial efficacycorona functionalizationepitope mediationnanoparticle alloyssurface component |
| spellingShingle | Edward Sacher Arthur Yelon A Pragmatic Perspective of the Antibacterial Properties of Metal-Based Nanoparticles Nanomaterials antibacterial efficacy corona functionalization epitope mediation nanoparticle alloys surface component |
| title | A Pragmatic Perspective of the Antibacterial Properties of Metal-Based Nanoparticles |
| title_full | A Pragmatic Perspective of the Antibacterial Properties of Metal-Based Nanoparticles |
| title_fullStr | A Pragmatic Perspective of the Antibacterial Properties of Metal-Based Nanoparticles |
| title_full_unstemmed | A Pragmatic Perspective of the Antibacterial Properties of Metal-Based Nanoparticles |
| title_short | A Pragmatic Perspective of the Antibacterial Properties of Metal-Based Nanoparticles |
| title_sort | pragmatic perspective of the antibacterial properties of metal based nanoparticles |
| topic | antibacterial efficacy corona functionalization epitope mediation nanoparticle alloys surface component |
| url | https://www.mdpi.com/2079-4991/11/12/3214 |
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