Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation
Telomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a long time only for its telomere lengthening function by reverse transcription of RNA template. Currently, TERT is considered as an intriguing link between multiple signaling pathways. The diverse intracellular l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/4/1091 |
| _version_ | 1797606311141048320 |
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| author | Anastasia I. Palamarchuk Elena I. Kovalenko Maria A. Streltsova |
| author_facet | Anastasia I. Palamarchuk Elena I. Kovalenko Maria A. Streltsova |
| author_sort | Anastasia I. Palamarchuk |
| collection | DOAJ |
| description | Telomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a long time only for its telomere lengthening function by reverse transcription of RNA template. Currently, TERT is considered as an intriguing link between multiple signaling pathways. The diverse intracellular localization of TERT corresponds to a wide range of functional activities. In addition to the canonical function of protecting chromosome ends, TERT by itself or as a part of the telomerase complex participates in cell stress responses, gene regulation and mitochondria functioning. Upregulation of TERT expression and increased telomerase activity in cancer and somatic cells relate to improved survival and persistence of such cells. In this review, we summarize the data for a comprehensive understanding of the role of TERT in cell death regulation, with a focus on the interaction of TERT with signaling pathways involved in cell survival and stress response. |
| first_indexed | 2024-03-11T05:13:24Z |
| format | Article |
| id | doaj.art-c689342ee9a2499182badd928e45e5f7 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T05:13:24Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c689342ee9a2499182badd928e45e5f72023-11-17T18:26:25ZengMDPI AGBiomedicines2227-90592023-04-01114109110.3390/biomedicines11041091Multiple Actions of Telomerase Reverse Transcriptase in Cell Death RegulationAnastasia I. Palamarchuk0Elena I. Kovalenko1Maria A. Streltsova2Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya 16/10, 117997 Moscow, RussiaShemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya 16/10, 117997 Moscow, RussiaShemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya 16/10, 117997 Moscow, RussiaTelomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a long time only for its telomere lengthening function by reverse transcription of RNA template. Currently, TERT is considered as an intriguing link between multiple signaling pathways. The diverse intracellular localization of TERT corresponds to a wide range of functional activities. In addition to the canonical function of protecting chromosome ends, TERT by itself or as a part of the telomerase complex participates in cell stress responses, gene regulation and mitochondria functioning. Upregulation of TERT expression and increased telomerase activity in cancer and somatic cells relate to improved survival and persistence of such cells. In this review, we summarize the data for a comprehensive understanding of the role of TERT in cell death regulation, with a focus on the interaction of TERT with signaling pathways involved in cell survival and stress response.https://www.mdpi.com/2227-9059/11/4/1091telomeraseTERTtelomerase reverse transcriptasetelomeresgene regulationstress |
| spellingShingle | Anastasia I. Palamarchuk Elena I. Kovalenko Maria A. Streltsova Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation Biomedicines telomerase TERT telomerase reverse transcriptase telomeres gene regulation stress |
| title | Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation |
| title_full | Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation |
| title_fullStr | Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation |
| title_full_unstemmed | Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation |
| title_short | Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation |
| title_sort | multiple actions of telomerase reverse transcriptase in cell death regulation |
| topic | telomerase TERT telomerase reverse transcriptase telomeres gene regulation stress |
| url | https://www.mdpi.com/2227-9059/11/4/1091 |
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