Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration

Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration

Abstract Microglia play an essential role for central nervous system (CNS) development and homeostasis and have been implicated in the onset, progression, and clearance of numerous diseases affecting the CNS. Previous in vitro research on human microglia was restricted to post-mortem brain tissue-de...

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Bibliographic Details
Main Authors: Anna M. Speicher, Heinz Wiendl, Sven G. Meuth, Matthias Pawlowski
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Molecular Neurodegeneration
Subjects:
Human microglia
Human pluripotent stem cells
Embryonic development
Differentiation
Human in vitro models
Neuroinflammation
Online Access:https://doi.org/10.1186/s13024-019-0347-z

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