Spectrophotometric determination of trifluoperazine via oxidative coupling reaction with sulfanilic acid
Abstract<br /> A simple spectrophotometric method has been developed for the determination of trifluoperazine hydrochloride in pure and in dosage forms. The method is based on the oxidative coupling reaction with sulfanilic acid in the presence of sodium hypochlorite in acetic acid medium to g...
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| Format: | Article |
| Language: | Arabic |
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College of Education for Pure Sciences
2010-03-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_57989_75d5d24de0c7db304f989aad63a98e23.pdf |
| _version_ | 1818144473281986560 |
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| author | Theiaa Al-Sabha Omar Al-Taee Maha Al-Obidi |
| author_facet | Theiaa Al-Sabha Omar Al-Taee Maha Al-Obidi |
| author_sort | Theiaa Al-Sabha |
| collection | DOAJ |
| description | Abstract<br /> A simple spectrophotometric method has been developed for the determination of trifluoperazine hydrochloride in pure and in dosage forms. The method is based on the oxidative coupling reaction with sulfanilic acid in the presence of sodium hypochlorite in acetic acid medium to give an red coloured product with absorption maximum at 510 nm. The product is stable for more than 6 h. Beer's law is obeyed over the concentration range of 0.2–7.0 µg ml-1 with molar absorptivity of 5.15×103 l.mol-1cm-1. Different experimental parameters affecting the development and stability of the formed coloured product were carefully studied and optimized and a proposal of the reaction pathway was presented. The proposed method was applied successfully to the determination of trifluoperazine hydrochloride in tablets and compared favorably with the official method. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed method. |
| first_indexed | 2024-12-11T11:48:07Z |
| format | Article |
| id | doaj.art-c69093b5611f4a5aa1df069bf6159239 |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-12-11T11:48:07Z |
| publishDate | 2010-03-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-c69093b5611f4a5aa1df069bf61592392022-12-22T01:08:26ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302010-03-0123161410.33899/edusj.2010.5798957989Spectrophotometric determination of trifluoperazine via oxidative coupling reaction with sulfanilic acidTheiaa Al-SabhaOmar Al-TaeeMaha Al-ObidiAbstract<br /> A simple spectrophotometric method has been developed for the determination of trifluoperazine hydrochloride in pure and in dosage forms. The method is based on the oxidative coupling reaction with sulfanilic acid in the presence of sodium hypochlorite in acetic acid medium to give an red coloured product with absorption maximum at 510 nm. The product is stable for more than 6 h. Beer's law is obeyed over the concentration range of 0.2–7.0 µg ml-1 with molar absorptivity of 5.15×103 l.mol-1cm-1. Different experimental parameters affecting the development and stability of the formed coloured product were carefully studied and optimized and a proposal of the reaction pathway was presented. The proposed method was applied successfully to the determination of trifluoperazine hydrochloride in tablets and compared favorably with the official method. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed method.https://edusj.mosuljournals.com/article_57989_75d5d24de0c7db304f989aad63a98e23.pdftrifluoperazineoxidative couplingsulfanilic acid |
| spellingShingle | Theiaa Al-Sabha Omar Al-Taee Maha Al-Obidi Spectrophotometric determination of trifluoperazine via oxidative coupling reaction with sulfanilic acid مجلة التربية والعلم trifluoperazine oxidative coupling sulfanilic acid |
| title | Spectrophotometric determination of trifluoperazine via oxidative coupling reaction with sulfanilic acid |
| title_full | Spectrophotometric determination of trifluoperazine via oxidative coupling reaction with sulfanilic acid |
| title_fullStr | Spectrophotometric determination of trifluoperazine via oxidative coupling reaction with sulfanilic acid |
| title_full_unstemmed | Spectrophotometric determination of trifluoperazine via oxidative coupling reaction with sulfanilic acid |
| title_short | Spectrophotometric determination of trifluoperazine via oxidative coupling reaction with sulfanilic acid |
| title_sort | spectrophotometric determination of trifluoperazine via oxidative coupling reaction with sulfanilic acid |
| topic | trifluoperazine oxidative coupling sulfanilic acid |
| url | https://edusj.mosuljournals.com/article_57989_75d5d24de0c7db304f989aad63a98e23.pdf |
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