Biologically active substances from water invertebrates: a review
Some species of invertebrates especially bryozoans (Bryozoa syn. Ectoprocta) and marine sponges (Porifera) are very important sources of pharmacologically exploitable compounds. These substances are probably produced to protect themselves from fish predators and may be an advantage in competition. T...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Czech Academy of Agricultural Sciences
2012-04-01
|
| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201204-0002_biologically-active-substances-from-water-invertebrates-a-review.php |
| _version_ | 1797897610921508864 |
|---|---|
| author | J. Sinko J. Rajchard Z. Balounova L. Fikotova |
| author_facet | J. Sinko J. Rajchard Z. Balounova L. Fikotova |
| author_sort | J. Sinko |
| collection | DOAJ |
| description | Some species of invertebrates especially bryozoans (Bryozoa syn. Ectoprocta) and marine sponges (Porifera) are very important sources of pharmacologically exploitable compounds. These substances are probably produced to protect themselves from fish predators and may be an advantage in competition. The real sources of compounds with these antipredatory effects are probably not marine invertebrates themselves, but microscopic symbionts or food which they feed on. Bryostatins from bryozoan species Bugula neritina are produced by a bacterial symbiont called Candidatus Endobugula sertula. They have significant anti-cancer effects, but also other therapeutic benefits. Compounds with the structure of bryostatins were also discovered in some other invertebrates. Sponges are a source of many compounds, e.g., ara-A (vidarabine), manzamine, lasonolides, spongistatins, peloruside and others with antimicrobial, anti-cancer, immunosuppressive and similar activities. Other important sources of compounds with medical effects are tunicates (Tunicata syn. Urochordata) and some snails (Mollusca). One drug was developed from tunicates - Yondelis against refractory soft-tissue sarcomas. Certain other drugs originate from snails: e.g., prialt, which acts against chronic pain in spinal cord injury. |
| first_indexed | 2024-04-10T08:01:12Z |
| format | Article |
| id | doaj.art-c690d1114d1a4ef19dd776e97a59ee5c |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T08:01:12Z |
| publishDate | 2012-04-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-c690d1114d1a4ef19dd776e97a59ee5c2023-02-23T03:50:02ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922012-04-0157417718410.17221/5914-VETMEDvet-201204-0002Biologically active substances from water invertebrates: a reviewJ. Sinko0J. Rajchard1Z. Balounova2L. Fikotova3Faculty of Fisheries and Protection of Waters, Vodnany, University of South Bohemia in Ceske Budejovice, Czech RepublicFaculty of Agriculture, University of South Bohemia in Ceske Budejovice, Czech RepublicFaculty of Agriculture, University of South Bohemia in Ceske Budejovice, Czech RepublicFaculty of Agriculture, University of South Bohemia in Ceske Budejovice, Czech RepublicSome species of invertebrates especially bryozoans (Bryozoa syn. Ectoprocta) and marine sponges (Porifera) are very important sources of pharmacologically exploitable compounds. These substances are probably produced to protect themselves from fish predators and may be an advantage in competition. The real sources of compounds with these antipredatory effects are probably not marine invertebrates themselves, but microscopic symbionts or food which they feed on. Bryostatins from bryozoan species Bugula neritina are produced by a bacterial symbiont called Candidatus Endobugula sertula. They have significant anti-cancer effects, but also other therapeutic benefits. Compounds with the structure of bryostatins were also discovered in some other invertebrates. Sponges are a source of many compounds, e.g., ara-A (vidarabine), manzamine, lasonolides, spongistatins, peloruside and others with antimicrobial, anti-cancer, immunosuppressive and similar activities. Other important sources of compounds with medical effects are tunicates (Tunicata syn. Urochordata) and some snails (Mollusca). One drug was developed from tunicates - Yondelis against refractory soft-tissue sarcomas. Certain other drugs originate from snails: e.g., prialt, which acts against chronic pain in spinal cord injury.https://vetmed.agriculturejournals.cz/artkey/vet-201204-0002_biologically-active-substances-from-water-invertebrates-a-review.phpbioactive substancesantipredatory effectcompetitionbryozoanbryostatinbugula neritinasymbiontmarine spongesisocyano terpenestunicatessnails |
| spellingShingle | J. Sinko J. Rajchard Z. Balounova L. Fikotova Biologically active substances from water invertebrates: a review Veterinární Medicína bioactive substances antipredatory effect competition bryozoan bryostatin bugula neritina symbiont marine sponges isocyano terpenes tunicates snails |
| title | Biologically active substances from water invertebrates: a review |
| title_full | Biologically active substances from water invertebrates: a review |
| title_fullStr | Biologically active substances from water invertebrates: a review |
| title_full_unstemmed | Biologically active substances from water invertebrates: a review |
| title_short | Biologically active substances from water invertebrates: a review |
| title_sort | biologically active substances from water invertebrates a review |
| topic | bioactive substances antipredatory effect competition bryozoan bryostatin bugula neritina symbiont marine sponges isocyano terpenes tunicates snails |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201204-0002_biologically-active-substances-from-water-invertebrates-a-review.php |
| work_keys_str_mv | AT jsinko biologicallyactivesubstancesfromwaterinvertebratesareview AT jrajchard biologicallyactivesubstancesfromwaterinvertebratesareview AT zbalounova biologicallyactivesubstancesfromwaterinvertebratesareview AT lfikotova biologicallyactivesubstancesfromwaterinvertebratesareview |