New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

A series of histamine (HST)-related compounds were synthesized and tested for their activating properties on five physiologically relevant human Carbonic Anhydrase (hCA) isoforms (I, II, Va, VII and XIII). The imidazole ring of HST was replaced with different 5-membered heterocycles and the length o...

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Bibliographic Details
Main Authors: Niccolò Chiaramonte, Alessio Gabellini, Andrea Angeli, Gianluca Bartolucci, Laura Braconi, Silvia Dei, Elisabetta Teodori, Claudiu T. Supuran, Maria Novella Romanelli
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
carbonic anhydrase activators
heterocycles
histamine-related compounds
Online Access:https://www.mdpi.com/1420-3049/27/2/545

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