Exogenous luteinizing hormone for assisted reproduction techniques in poor response patients
Background/Aim. Two gonadotrophins, two cell theory refers to necessity of both gonadotrophin activities for theca and granulose cells steroidogenesis of dominant follicle. The aim of this study was to determine the influence of recombinant LH in women qualified as poor responders in the first assis...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2010-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501007569S.pdf |
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| author | Spremović-Rađenović Svetlana Gudović Aleksandra Lazović Gordana |
| author_facet | Spremović-Rađenović Svetlana Gudović Aleksandra Lazović Gordana |
| author_sort | Spremović-Rađenović Svetlana |
| collection | DOAJ |
| description | Background/Aim. Two gonadotrophins, two cell theory refers to necessity of both gonadotrophin activities for theca and granulose cells steroidogenesis of dominant follicle. The aim of this study was to determine the influence of recombinant LH in women qualified as poor responders in the first assisted reproduction procedure (IVF), on fertility results, expressed as percentage of clinical pregnancies. Method. The study included 12 women, 35 years and older who were their own controls. The next trial of IVF was with the same dose of recombinant FSH and GnRH agonist, and with the same, long protocol. Recombinant LH was added in the dose of 75 IU from the 2nd to 7th day of the cycle, and 150 IU from the 8th day of the cycle to the aspiration of oocytes. Results. Within the two different protocols: there was no significant difference between LH concentration in 8th and 12th day of cycle; there was no significant difference between E2 concentration on day 2nd and day 8th; there was a significant difference between E2 concentrations on day 12th; endometrial thickness was not significantly different on the day of aspiration, neither was the number of follicles and embryos. In the two patients, clinical pregnancy was detected (pregnancy rate 17%), and they delivered in term. So, a statistically significant difference between the two protocols was in the rate of clinical pregnancies. Conclusion. The patients with low response to a long protocol in IVF procedures had significantly better results according to the clinical pregnancy rate when the recombinant LH was added to recombinant FSH in the stimulation protocol. |
| first_indexed | 2024-04-12T23:36:21Z |
| format | Article |
| id | doaj.art-c692afd5261842f49f882e67508efa8e |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-04-12T23:36:21Z |
| publishDate | 2010-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-c692afd5261842f49f882e67508efa8e2022-12-22T03:12:09ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502010-01-0167756957210.2298/VSP1007569SExogenous luteinizing hormone for assisted reproduction techniques in poor response patientsSpremović-Rađenović SvetlanaGudović AleksandraLazović GordanaBackground/Aim. Two gonadotrophins, two cell theory refers to necessity of both gonadotrophin activities for theca and granulose cells steroidogenesis of dominant follicle. The aim of this study was to determine the influence of recombinant LH in women qualified as poor responders in the first assisted reproduction procedure (IVF), on fertility results, expressed as percentage of clinical pregnancies. Method. The study included 12 women, 35 years and older who were their own controls. The next trial of IVF was with the same dose of recombinant FSH and GnRH agonist, and with the same, long protocol. Recombinant LH was added in the dose of 75 IU from the 2nd to 7th day of the cycle, and 150 IU from the 8th day of the cycle to the aspiration of oocytes. Results. Within the two different protocols: there was no significant difference between LH concentration in 8th and 12th day of cycle; there was no significant difference between E2 concentration on day 2nd and day 8th; there was a significant difference between E2 concentrations on day 12th; endometrial thickness was not significantly different on the day of aspiration, neither was the number of follicles and embryos. In the two patients, clinical pregnancy was detected (pregnancy rate 17%), and they delivered in term. So, a statistically significant difference between the two protocols was in the rate of clinical pregnancies. Conclusion. The patients with low response to a long protocol in IVF procedures had significantly better results according to the clinical pregnancy rate when the recombinant LH was added to recombinant FSH in the stimulation protocol.http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501007569S.pdffertilization in vitroluteinizing hormoneovulation induction |
| spellingShingle | Spremović-Rađenović Svetlana Gudović Aleksandra Lazović Gordana Exogenous luteinizing hormone for assisted reproduction techniques in poor response patients Vojnosanitetski Pregled fertilization in vitro luteinizing hormone ovulation induction |
| title | Exogenous luteinizing hormone for assisted reproduction techniques in poor response patients |
| title_full | Exogenous luteinizing hormone for assisted reproduction techniques in poor response patients |
| title_fullStr | Exogenous luteinizing hormone for assisted reproduction techniques in poor response patients |
| title_full_unstemmed | Exogenous luteinizing hormone for assisted reproduction techniques in poor response patients |
| title_short | Exogenous luteinizing hormone for assisted reproduction techniques in poor response patients |
| title_sort | exogenous luteinizing hormone for assisted reproduction techniques in poor response patients |
| topic | fertilization in vitro luteinizing hormone ovulation induction |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501007569S.pdf |
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