The diagnostic significance of neurofilament heavy chains in cerebrospinal fluid in amyotrophic lateral sclerosis

The diagnostic significance of neurofilament heavy chains in cerebrospinal fluid in amyotrophic lateral sclerosis

Introduction. Early diagnosis of amyotrophic lateral sclerosis (ALS) is difficult because of the low sensitivity of clinical criteria at the early stages of the disease and the lack of reliable laboratory biomarkers. Neuron destruction leads to the release of excessively accumulated phosphorylated n...

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Main Authors: Anastasia V. Vladykina, Vladimir D. Nazarov, Vladimir S. Krasnov, Ekaterina I. Koroleva, Polina A. Fedorova, Anna N. Moshnikova, Aleksandra V. Mazing, Sergey V. Lapin, Vladimir L. Emanuel, Dmitriy I. Rudenko, Fatima R. Stuchevskaya, Sergey M. Zatakovenko, Tatyana A. Pavlova, Tatyana M. Alekseeva, Vitaliy V. Goldobin
Format: Article
Language:English
Published: Research Center of Neurology 2021-03-01
Series:Анналы клинической и экспериментальной неврологии
Subjects:
amyotrophic lateral sclerosis
neurofilaments
neurofilament heavy chains
biomarkers
Online Access:https://annaly-nevrologii.com/journal/pathID/article/viewFile/724/565

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