Distinct role of 5′UTR sequences in dendritic trafficking of BDNF mRNA: additional mechanisms for the BDNF splice variants spatial code

Distinct role of 5′UTR sequences in dendritic trafficking of BDNF mRNA: additional mechanisms for the BDNF splice variants spatial code

Abstract The neurotrophin Brain-derived neurotrophic factor (BDNF) is encoded by multiple bipartite transcripts. Each BDNF transcript is composed by one out of 11 alternatively spliced exons containing the 5′untranslated region (UTR), and one common exon encompassing the coding sequence (CDS) and th...

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Bibliographic Details
Main Authors: Andrea Colliva, Enrico Tongiorgi
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Brain
Subjects:
Neurotrophic factors
BDNF mRNA
RNA localization
Neuronal dendrites
Transport mechanism
Dendritic targeting elements
Online Access:https://doi.org/10.1186/s13041-020-00680-8

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