Role of SNAREs and Rabs in Myelin Regulation
The myelin sheath is an insulating layer around the nerves of the brain and spinal cord which allows a fast and efficient nerve conduction. Myelin is made of protein and fatty substances and gives protection for the propagation of the electrical impulse. The myelin sheath is formed by oligodendrocyt...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9772 |
| _version_ | 1797597350135332864 |
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| author | Azzurra Margiotta |
| author_facet | Azzurra Margiotta |
| author_sort | Azzurra Margiotta |
| collection | DOAJ |
| description | The myelin sheath is an insulating layer around the nerves of the brain and spinal cord which allows a fast and efficient nerve conduction. Myelin is made of protein and fatty substances and gives protection for the propagation of the electrical impulse. The myelin sheath is formed by oligodendrocytes in the central nervous system (CNS) and by Schwann cells in the peripheral nervous system (PNS). The myelin sheath presents a highly organized structure and expands both radially and longitudinally, but in a different way and with a different composition. Myelin alterations determine the onset of several neuropathies, as the electrical signal can be slowed or stopped. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and ras (rat sarcoma)-associated binding proteins (rabs) have been proved to contribute to several aspects regarding the formation of myelin or dysmyelination. Here, I will describe the role of these proteins in regulating membrane trafficking and nerve conduction, myelin biogenesis and maintenance. |
| first_indexed | 2024-03-11T03:04:59Z |
| format | Article |
| id | doaj.art-c699dabdeb234233a15c1e39bc1df8b8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:04:59Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c699dabdeb234233a15c1e39bc1df8b82023-11-18T08:03:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-012411977210.3390/ijms24119772Role of SNAREs and Rabs in Myelin RegulationAzzurra Margiotta0Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, NorwayThe myelin sheath is an insulating layer around the nerves of the brain and spinal cord which allows a fast and efficient nerve conduction. Myelin is made of protein and fatty substances and gives protection for the propagation of the electrical impulse. The myelin sheath is formed by oligodendrocytes in the central nervous system (CNS) and by Schwann cells in the peripheral nervous system (PNS). The myelin sheath presents a highly organized structure and expands both radially and longitudinally, but in a different way and with a different composition. Myelin alterations determine the onset of several neuropathies, as the electrical signal can be slowed or stopped. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and ras (rat sarcoma)-associated binding proteins (rabs) have been proved to contribute to several aspects regarding the formation of myelin or dysmyelination. Here, I will describe the role of these proteins in regulating membrane trafficking and nerve conduction, myelin biogenesis and maintenance.https://www.mdpi.com/1422-0067/24/11/9772SNAREsrabsneurotransmitter releasemyelin |
| spellingShingle | Azzurra Margiotta Role of SNAREs and Rabs in Myelin Regulation International Journal of Molecular Sciences SNAREs rabs neurotransmitter release myelin |
| title | Role of SNAREs and Rabs in Myelin Regulation |
| title_full | Role of SNAREs and Rabs in Myelin Regulation |
| title_fullStr | Role of SNAREs and Rabs in Myelin Regulation |
| title_full_unstemmed | Role of SNAREs and Rabs in Myelin Regulation |
| title_short | Role of SNAREs and Rabs in Myelin Regulation |
| title_sort | role of snares and rabs in myelin regulation |
| topic | SNAREs rabs neurotransmitter release myelin |
| url | https://www.mdpi.com/1422-0067/24/11/9772 |
| work_keys_str_mv | AT azzurramargiotta roleofsnaresandrabsinmyelinregulation |