FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer.
Gene fusion is a chromosomal rearrangement event which plays a significant role in cancer due to the oncogenic potential of the chimeric protein generated through fusions. At present many databases are available in public domain which provides detailed information about known gene fusion events and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5929557?pdf=render |
| _version_ | 1818516136401043456 |
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| author | Priyabrata Panigrahi Abhay Jere Krishanpal Anamika |
| author_facet | Priyabrata Panigrahi Abhay Jere Krishanpal Anamika |
| author_sort | Priyabrata Panigrahi |
| collection | DOAJ |
| description | Gene fusion is a chromosomal rearrangement event which plays a significant role in cancer due to the oncogenic potential of the chimeric protein generated through fusions. At present many databases are available in public domain which provides detailed information about known gene fusion events and their functional role. Existing gene fusion detection tools, based on analysis of transcriptomics data usually report a large number of fusion genes as potential candidates, which could be either known or novel or false positives. Manual annotation of these putative genes is indeed time-consuming. We have developed a web platform FusionHub, which acts as integrated search engine interfacing various fusion gene databases and simplifies large scale annotation of fusion genes in a seamless way. In addition, FusionHub provides three ways of visualizing fusion events: circular view, domain architecture view and network view. Design of potential siRNA molecules through ensemble method is another utility integrated in FusionHub that could aid in siRNA-based targeted therapy. FusionHub is freely available at https://fusionhub.persistent.co.in. |
| first_indexed | 2024-12-11T00:38:06Z |
| format | Article |
| id | doaj.art-c69a2789a7a1400bb406bd872f822f06 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T00:38:06Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c69a2789a7a1400bb406bd872f822f062022-12-22T01:27:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01135e019658810.1371/journal.pone.0196588FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer.Priyabrata PanigrahiAbhay JereKrishanpal AnamikaGene fusion is a chromosomal rearrangement event which plays a significant role in cancer due to the oncogenic potential of the chimeric protein generated through fusions. At present many databases are available in public domain which provides detailed information about known gene fusion events and their functional role. Existing gene fusion detection tools, based on analysis of transcriptomics data usually report a large number of fusion genes as potential candidates, which could be either known or novel or false positives. Manual annotation of these putative genes is indeed time-consuming. We have developed a web platform FusionHub, which acts as integrated search engine interfacing various fusion gene databases and simplifies large scale annotation of fusion genes in a seamless way. In addition, FusionHub provides three ways of visualizing fusion events: circular view, domain architecture view and network view. Design of potential siRNA molecules through ensemble method is another utility integrated in FusionHub that could aid in siRNA-based targeted therapy. FusionHub is freely available at https://fusionhub.persistent.co.in.http://europepmc.org/articles/PMC5929557?pdf=render |
| spellingShingle | Priyabrata Panigrahi Abhay Jere Krishanpal Anamika FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer. PLoS ONE |
| title | FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer. |
| title_full | FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer. |
| title_fullStr | FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer. |
| title_full_unstemmed | FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer. |
| title_short | FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer. |
| title_sort | fusionhub a unified web platform for annotation and visualization of gene fusion events in human cancer |
| url | http://europepmc.org/articles/PMC5929557?pdf=render |
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