Exploring the pan-cancer landscape of posttranscriptional regulation
Summary: Understanding the mechanisms underlying cancer gene expression is critical for precision oncology. Posttranscriptional regulation is a key determinant of protein abundance and cancer cell behavior. However, to what extent posttranscriptional regulatory mechanisms impact protein levels and c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723011841 |
| _version_ | 1827808443753299968 |
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| author | Umesh Ghoshdastider Ataman Sendoel |
| author_facet | Umesh Ghoshdastider Ataman Sendoel |
| author_sort | Umesh Ghoshdastider |
| collection | DOAJ |
| description | Summary: Understanding the mechanisms underlying cancer gene expression is critical for precision oncology. Posttranscriptional regulation is a key determinant of protein abundance and cancer cell behavior. However, to what extent posttranscriptional regulatory mechanisms impact protein levels and cancer progression is an ongoing question. Here, we exploit cancer proteogenomics data to systematically compare mRNA-protein correlations across 14 different human cancer types. We identify two clusters of genes with particularly low mRNA-protein correlations across all cancer types, shed light on the role of posttranscriptional regulation of cancer driver genes and drug targets, and unveil a cohort of 55 mutations that alter systems-wide posttranscriptional regulation. Surprisingly, we find that decreased levels of posttranscriptional control in patients correlate with shorter overall survival across multiple cancer types, prompting further mechanistic studies into how posttranscriptional regulation affects patient outcomes. Our findings underscore the importance of a comprehensive understanding of the posttranscriptional regulatory landscape for predicting cancer progression. |
| first_indexed | 2024-03-11T22:27:12Z |
| format | Article |
| id | doaj.art-c69b0bb1a5194467a0978675a6f53e7a |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-11T22:27:12Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-c69b0bb1a5194467a0978675a6f53e7a2023-09-24T05:15:04ZengElsevierCell Reports2211-12472023-10-014210113172Exploring the pan-cancer landscape of posttranscriptional regulationUmesh Ghoshdastider0Ataman Sendoel1Institute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952 Schlieren-Zurich, SwitzerlandInstitute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952 Schlieren-Zurich, Switzerland; Corresponding authorSummary: Understanding the mechanisms underlying cancer gene expression is critical for precision oncology. Posttranscriptional regulation is a key determinant of protein abundance and cancer cell behavior. However, to what extent posttranscriptional regulatory mechanisms impact protein levels and cancer progression is an ongoing question. Here, we exploit cancer proteogenomics data to systematically compare mRNA-protein correlations across 14 different human cancer types. We identify two clusters of genes with particularly low mRNA-protein correlations across all cancer types, shed light on the role of posttranscriptional regulation of cancer driver genes and drug targets, and unveil a cohort of 55 mutations that alter systems-wide posttranscriptional regulation. Surprisingly, we find that decreased levels of posttranscriptional control in patients correlate with shorter overall survival across multiple cancer types, prompting further mechanistic studies into how posttranscriptional regulation affects patient outcomes. Our findings underscore the importance of a comprehensive understanding of the posttranscriptional regulatory landscape for predicting cancer progression.http://www.sciencedirect.com/science/article/pii/S2211124723011841CP: CancerCP: Genomics |
| spellingShingle | Umesh Ghoshdastider Ataman Sendoel Exploring the pan-cancer landscape of posttranscriptional regulation Cell Reports CP: Cancer CP: Genomics |
| title | Exploring the pan-cancer landscape of posttranscriptional regulation |
| title_full | Exploring the pan-cancer landscape of posttranscriptional regulation |
| title_fullStr | Exploring the pan-cancer landscape of posttranscriptional regulation |
| title_full_unstemmed | Exploring the pan-cancer landscape of posttranscriptional regulation |
| title_short | Exploring the pan-cancer landscape of posttranscriptional regulation |
| title_sort | exploring the pan cancer landscape of posttranscriptional regulation |
| topic | CP: Cancer CP: Genomics |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723011841 |
| work_keys_str_mv | AT umeshghoshdastider exploringthepancancerlandscapeofposttranscriptionalregulation AT atamansendoel exploringthepancancerlandscapeofposttranscriptionalregulation |