Objective sleep was longitudinally associated with brain amyloid burden in mild cognitive impairment
Abstract Objective Understanding the longitudinal association of objective sleep and physical activity with brain amyloid burden and cortical glucose metabolism has critical clinical and public health implications for dementia prevention in later life. Methods We enrolled 118 individuals aged ≥65 ye...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51912 |
| _version_ | 1797389838642577408 |
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| author | Noriyuki Kimura Yuuki Sasaki Teruaki Masuda Takuya Ataka Atsuko Eguchi Tatsuyuki Kakuma Etsuro Matsubara |
| author_facet | Noriyuki Kimura Yuuki Sasaki Teruaki Masuda Takuya Ataka Atsuko Eguchi Tatsuyuki Kakuma Etsuro Matsubara |
| author_sort | Noriyuki Kimura |
| collection | DOAJ |
| description | Abstract Objective Understanding the longitudinal association of objective sleep and physical activity with brain amyloid burden and cortical glucose metabolism has critical clinical and public health implications for dementia prevention in later life. Methods We enrolled 118 individuals aged ≥65 years with mild cognitive impairment, who were followed up on from August 2015 to September 2019. All participants continuously wore an accelerometer sensor for 7 consecutive days every 3 months and received annual 11C‐Pittsburgh compound‐B and 18F‐fluorodeoxyglucose positron emission tomography (PET). Sleep and physical activity parameters were assessed using accelerometer sensor data and PET imaging was quantified using a standardized uptake‐value ratio. Fifty‐seven participants (48.3%) completed a lifestyle factor assessment and PET imaging over the 3‐year period. A linear mixed‐effects model was applied to examine the longitudinal association of sleep and physical activity parameters with PET imaging over the 3‐year period, controlling for potential confounders. Results Sleep efficiency was inversely associated with amyloid uptake in the frontal lobe. Although sleep duration was positively associated with global amyloid uptake, particularly in the frontal lobe, their impact was extremely small. However, physical activity parameters were not significantly associated with the 11C‐Pittsburgh compound‐B‐uptake. Furthermore, sleep and physical activity parameters were not significantly associated with cortical glucose metabolism. Interpretation Lower sleep efficiency could be an early symptom of greater brain amyloid burden at the mild cognitive impairment stage. Therefore, the assessment of sleep may be useful for identifying individuals at higher risk for brain amyloid burden. Future longer term observational studies are required to confirm these findings. |
| first_indexed | 2024-03-08T23:01:48Z |
| format | Article |
| id | doaj.art-c69b7ed13f794afcb855e2b4bbb18ea2 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-03-08T23:01:48Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-c69b7ed13f794afcb855e2b4bbb18ea22023-12-15T16:39:24ZengWileyAnnals of Clinical and Translational Neurology2328-95032023-12-0110122266227510.1002/acn3.51912Objective sleep was longitudinally associated with brain amyloid burden in mild cognitive impairmentNoriyuki Kimura0Yuuki Sasaki1Teruaki Masuda2Takuya Ataka3Atsuko Eguchi4Tatsuyuki Kakuma5Etsuro Matsubara6Department of Neurology, Faculty of Medicine Oita University Oita JapanDepartment of Neurology, Faculty of Medicine Oita University Oita JapanDepartment of Neurology, Faculty of Medicine Oita University Oita JapanDepartment of Neurology, Faculty of Medicine Oita University Oita JapanDepartment of Neurology, Faculty of Medicine Oita University Oita JapanBiostatistics Center Kurume University Kurume JapanDepartment of Neurology, Faculty of Medicine Oita University Oita JapanAbstract Objective Understanding the longitudinal association of objective sleep and physical activity with brain amyloid burden and cortical glucose metabolism has critical clinical and public health implications for dementia prevention in later life. Methods We enrolled 118 individuals aged ≥65 years with mild cognitive impairment, who were followed up on from August 2015 to September 2019. All participants continuously wore an accelerometer sensor for 7 consecutive days every 3 months and received annual 11C‐Pittsburgh compound‐B and 18F‐fluorodeoxyglucose positron emission tomography (PET). Sleep and physical activity parameters were assessed using accelerometer sensor data and PET imaging was quantified using a standardized uptake‐value ratio. Fifty‐seven participants (48.3%) completed a lifestyle factor assessment and PET imaging over the 3‐year period. A linear mixed‐effects model was applied to examine the longitudinal association of sleep and physical activity parameters with PET imaging over the 3‐year period, controlling for potential confounders. Results Sleep efficiency was inversely associated with amyloid uptake in the frontal lobe. Although sleep duration was positively associated with global amyloid uptake, particularly in the frontal lobe, their impact was extremely small. However, physical activity parameters were not significantly associated with the 11C‐Pittsburgh compound‐B‐uptake. Furthermore, sleep and physical activity parameters were not significantly associated with cortical glucose metabolism. Interpretation Lower sleep efficiency could be an early symptom of greater brain amyloid burden at the mild cognitive impairment stage. Therefore, the assessment of sleep may be useful for identifying individuals at higher risk for brain amyloid burden. Future longer term observational studies are required to confirm these findings.https://doi.org/10.1002/acn3.51912 |
| spellingShingle | Noriyuki Kimura Yuuki Sasaki Teruaki Masuda Takuya Ataka Atsuko Eguchi Tatsuyuki Kakuma Etsuro Matsubara Objective sleep was longitudinally associated with brain amyloid burden in mild cognitive impairment Annals of Clinical and Translational Neurology |
| title | Objective sleep was longitudinally associated with brain amyloid burden in mild cognitive impairment |
| title_full | Objective sleep was longitudinally associated with brain amyloid burden in mild cognitive impairment |
| title_fullStr | Objective sleep was longitudinally associated with brain amyloid burden in mild cognitive impairment |
| title_full_unstemmed | Objective sleep was longitudinally associated with brain amyloid burden in mild cognitive impairment |
| title_short | Objective sleep was longitudinally associated with brain amyloid burden in mild cognitive impairment |
| title_sort | objective sleep was longitudinally associated with brain amyloid burden in mild cognitive impairment |
| url | https://doi.org/10.1002/acn3.51912 |
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