Cognitive profiles of genetic syndromes with Intellectual Disability
The study of similarities and differences in the cognitive profiles of persons with genetic-based Intellectual Disability is relevant to increase our understanding about the complex way in which genetic aspects affect cognitive processes.Genetic syndromes have been mainly studied with reference to w...
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| Format: | Article |
| Language: | English |
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Associazione Oasi Maria SS. - Troina
2009-06-01
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| Series: | Life Span and Disability |
| Subjects: | |
| Online Access: | http://www.lifespan.it/client/abstract/ENG128_life%20span%20edit+2%20engl.pdf |
| _version_ | 1818381432204034048 |
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| author | Di Nuovo, Santo Buono, Serafino |
| author_facet | Di Nuovo, Santo Buono, Serafino |
| author_sort | Di Nuovo, Santo |
| collection | DOAJ |
| description | The study of similarities and differences in the cognitive profiles of persons with genetic-based Intellectual Disability is relevant to increase our understanding about the complex way in which genetic aspects affect cognitive processes.Genetic syndromes have been mainly studied with reference to within profile variability.The aim of our study was to compare cognitive syndrome profiles in order to detect those cognitive variables that better characterize each syndrome.Wechsler Intelligence Scale for Children was administered in a samplecomposed of 156 persons with mild or moderate Intellectual Disability, 94 males and 62 females, divided into four groups according to their genetic syndrome (Down or Trisomy-21,Williams, Prader-Willi, Fragile-X).The groups were paired on chronological and mental ages and levels ofmaladaptive behaviors.Variance analysis across syndromes, followed by a discriminant analysis, were performed for all the variables.Results showed that the delay in cognitive functions is higher in attention-concentration and visuo-spatial constructive skills than in verbal skills.The genetic syndromes had different profiles, with a higher level for Prader-Willi than for Down and Fragile-X; the intra-profile disharmony was lower in Down and higher in Williams syndrome.Discriminant analysis allowed us to detect the best discriminating subtests in the classification of syndromes based on cognitive points of strength and weakness.Our results supported the hypothesis that Intellectual Disability reflects the impaired functioning of a complex system in which some skills are damaged more than others.The question of “what discriminates better among syndromes”may be answered assuming a “modular” perspective of mind in disability. To analyze what abilities are specifically impaired in each syndrome, is useful to plan specific rehabilitation procedures. |
| first_indexed | 2024-12-14T02:34:29Z |
| format | Article |
| id | doaj.art-c69b8d1e71954ec8b146a7451cb64f01 |
| institution | Directory Open Access Journal |
| issn | 2035-5963 |
| language | English |
| last_indexed | 2024-12-14T02:34:29Z |
| publishDate | 2009-06-01 |
| publisher | Associazione Oasi Maria SS. - Troina |
| record_format | Article |
| series | Life Span and Disability |
| spelling | doaj.art-c69b8d1e71954ec8b146a7451cb64f012022-12-21T23:20:10ZengAssociazione Oasi Maria SS. - TroinaLife Span and Disability2035-59632009-06-01XII12940Cognitive profiles of genetic syndromes with Intellectual DisabilityDi Nuovo, SantoBuono, SerafinoThe study of similarities and differences in the cognitive profiles of persons with genetic-based Intellectual Disability is relevant to increase our understanding about the complex way in which genetic aspects affect cognitive processes.Genetic syndromes have been mainly studied with reference to within profile variability.The aim of our study was to compare cognitive syndrome profiles in order to detect those cognitive variables that better characterize each syndrome.Wechsler Intelligence Scale for Children was administered in a samplecomposed of 156 persons with mild or moderate Intellectual Disability, 94 males and 62 females, divided into four groups according to their genetic syndrome (Down or Trisomy-21,Williams, Prader-Willi, Fragile-X).The groups were paired on chronological and mental ages and levels ofmaladaptive behaviors.Variance analysis across syndromes, followed by a discriminant analysis, were performed for all the variables.Results showed that the delay in cognitive functions is higher in attention-concentration and visuo-spatial constructive skills than in verbal skills.The genetic syndromes had different profiles, with a higher level for Prader-Willi than for Down and Fragile-X; the intra-profile disharmony was lower in Down and higher in Williams syndrome.Discriminant analysis allowed us to detect the best discriminating subtests in the classification of syndromes based on cognitive points of strength and weakness.Our results supported the hypothesis that Intellectual Disability reflects the impaired functioning of a complex system in which some skills are damaged more than others.The question of “what discriminates better among syndromes”may be answered assuming a “modular” perspective of mind in disability. To analyze what abilities are specifically impaired in each syndrome, is useful to plan specific rehabilitation procedures.http://www.lifespan.it/client/abstract/ENG128_life%20span%20edit+2%20engl.pdfGenetic syndromesIntellectual DisabilityPhenotypeCognitive profiles |
| spellingShingle | Di Nuovo, Santo Buono, Serafino Cognitive profiles of genetic syndromes with Intellectual Disability Life Span and Disability Genetic syndromes Intellectual Disability Phenotype Cognitive profiles |
| title | Cognitive profiles of genetic syndromes with Intellectual Disability |
| title_full | Cognitive profiles of genetic syndromes with Intellectual Disability |
| title_fullStr | Cognitive profiles of genetic syndromes with Intellectual Disability |
| title_full_unstemmed | Cognitive profiles of genetic syndromes with Intellectual Disability |
| title_short | Cognitive profiles of genetic syndromes with Intellectual Disability |
| title_sort | cognitive profiles of genetic syndromes with intellectual disability |
| topic | Genetic syndromes Intellectual Disability Phenotype Cognitive profiles |
| url | http://www.lifespan.it/client/abstract/ENG128_life%20span%20edit+2%20engl.pdf |
| work_keys_str_mv | AT dinuovosanto cognitiveprofilesofgeneticsyndromeswithintellectualdisability AT buonoserafino cognitiveprofilesofgeneticsyndromeswithintellectualdisability |