Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior Uveitis
<i>Background and Objectives:</i> A cross-sectional single-center study was conducted to investigate the etiology in hypertensive anterior uveitis whose clinical features are not fully distinctive from cytomegalovirus or from rubella virus and to demonstrate the possible coexistence of b...
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MDPI AG
2022-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/8/1054 |
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| author | Fabrizio Gozzi Lucia Belloni Raffaella Aldigeri Pietro Gentile Valentina Mastrofilippo Luca De Simone Elena Bolletta Federica Alessandrello Martina Bonacini Stefania Croci Alessandro Zerbini Gian Maria Cavallini Carlo Salvarani Luca Cimino |
| author_facet | Fabrizio Gozzi Lucia Belloni Raffaella Aldigeri Pietro Gentile Valentina Mastrofilippo Luca De Simone Elena Bolletta Federica Alessandrello Martina Bonacini Stefania Croci Alessandro Zerbini Gian Maria Cavallini Carlo Salvarani Luca Cimino |
| author_sort | Fabrizio Gozzi |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> A cross-sectional single-center study was conducted to investigate the etiology in hypertensive anterior uveitis whose clinical features are not fully distinctive from cytomegalovirus or from rubella virus and to demonstrate the possible coexistence of both these viruses in causing anterior uveitis. <i>Materials and Methods:</i> The clinical charts of a cohort of patients with hypertensive viral anterior uveitis of uncertain origin consecutively seen in a single center from 2019 to 2022 were retrospectively reviewed; data on the clinical features, aqueous polymerase chain reaction, and antibody response to cytomegalovirus and rubella virus were collected. <i>Results:</i> Forty-three eyes of as many subjects with viral anterior uveitis of uncertain origin were included. Thirty-two patients had an aqueous polymerase chain reaction or antibody index positive to cytomegalovirus only, while 11 cases had an aqueous antibody response to both cytomegalovirus and rubella virus. This latter overlapping group had a statistically significant higher rate of hypochromia and anterior vitritis (<i>p</i>-value: 0.02 and < 0.001, respectively). <i>Conclusions:</i> The simultaneous presence of intraocular antibodies against cytomegalovirus and rubella virus could redefine the differential diagnosis of hypertensive viral anterior uveitis, demonstrating a possible “converged” immune pathway consisting in a variety of stimuli. |
| first_indexed | 2024-03-09T04:06:57Z |
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| id | doaj.art-c69ec846e0534d72856c90b76f0b1c9b |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T04:06:57Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-c69ec846e0534d72856c90b76f0b1c9b2023-12-03T14:04:44ZengMDPI AGMedicina1010-660X1648-91442022-08-01588105410.3390/medicina58081054Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior UveitisFabrizio Gozzi0Lucia Belloni1Raffaella Aldigeri2Pietro Gentile3Valentina Mastrofilippo4Luca De Simone5Elena Bolletta6Federica Alessandrello7Martina Bonacini8Stefania Croci9Alessandro Zerbini10Gian Maria Cavallini11Carlo Salvarani12Luca Cimino13Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, ItalyClinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, ItalyDepartment of Medicine and Surgery, University of Parma, 43100 Parma, ItalyDepartment of Surgical Sciences, Eye Clinic, University of Cagliari, 09124 Cagliari, ItalyOcular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, ItalyOcular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, ItalyOcular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, ItalyDepartment of Biomedical Sciences, Ophthalmology Clinic, University Hospital of Messina, 98125 Messina, ItalyClinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, ItalyClinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, ItalyClinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, ItalyDepartment of Surgery, Medicine, Dentistry and Morphological Sciences, with Interest in Transplants, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41121 Modena, ItalyDepartment of Surgery, Medicine, Dentistry and Morphological Sciences, with Interest in Transplants, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41121 Modena, ItalyOcular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy<i>Background and Objectives:</i> A cross-sectional single-center study was conducted to investigate the etiology in hypertensive anterior uveitis whose clinical features are not fully distinctive from cytomegalovirus or from rubella virus and to demonstrate the possible coexistence of both these viruses in causing anterior uveitis. <i>Materials and Methods:</i> The clinical charts of a cohort of patients with hypertensive viral anterior uveitis of uncertain origin consecutively seen in a single center from 2019 to 2022 were retrospectively reviewed; data on the clinical features, aqueous polymerase chain reaction, and antibody response to cytomegalovirus and rubella virus were collected. <i>Results:</i> Forty-three eyes of as many subjects with viral anterior uveitis of uncertain origin were included. Thirty-two patients had an aqueous polymerase chain reaction or antibody index positive to cytomegalovirus only, while 11 cases had an aqueous antibody response to both cytomegalovirus and rubella virus. This latter overlapping group had a statistically significant higher rate of hypochromia and anterior vitritis (<i>p</i>-value: 0.02 and < 0.001, respectively). <i>Conclusions:</i> The simultaneous presence of intraocular antibodies against cytomegalovirus and rubella virus could redefine the differential diagnosis of hypertensive viral anterior uveitis, demonstrating a possible “converged” immune pathway consisting in a variety of stimuli.https://www.mdpi.com/1648-9144/58/8/1054overlapping viral anterior uveitiscytomegalovirusrubella virusFuchs Uveitisantibody index |
| spellingShingle | Fabrizio Gozzi Lucia Belloni Raffaella Aldigeri Pietro Gentile Valentina Mastrofilippo Luca De Simone Elena Bolletta Federica Alessandrello Martina Bonacini Stefania Croci Alessandro Zerbini Gian Maria Cavallini Carlo Salvarani Luca Cimino Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior Uveitis Medicina overlapping viral anterior uveitis cytomegalovirus rubella virus Fuchs Uveitis antibody index |
| title | Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior Uveitis |
| title_full | Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior Uveitis |
| title_fullStr | Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior Uveitis |
| title_full_unstemmed | Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior Uveitis |
| title_short | Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior Uveitis |
| title_sort | aqueous humor analysis in overlapping clinical diagnosis of cytomegalovirus and rubella virus anterior uveitis |
| topic | overlapping viral anterior uveitis cytomegalovirus rubella virus Fuchs Uveitis antibody index |
| url | https://www.mdpi.com/1648-9144/58/8/1054 |
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