Molecular Dynamics Simulations of a Cytochrome P450 from <i>Tepidiphilus thermophilus</i> (P450-TT) Reveal How Its Substrate-Binding Channel Opens

Molecular Dynamics Simulations of a Cytochrome P450 from <i>Tepidiphilus thermophilus</i> (P450-TT) Reveal How Its Substrate-Binding Channel Opens

Cytochrome P450s (P450) are important enzymes in biology with useful biochemical reactions in, for instance, drug and xenobiotics metabolisms, biotechnology, and health. Recently, the crystal structure of a new member of the CYP116B family has been resolved. This enzyme is a cytochrome P450 (CYP116B...

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Bibliographic Details
Main Authors: Abayomi S. Faponle, Anupom Roy, Ayodeji A. Adelegan, James W. Gauld
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
cytochrome P450
CYP
gating
P450-TT
CYP116B46
substrate channel
Online Access:https://www.mdpi.com/1420-3049/26/12/3614

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