Different types of Status Epilepticus may lead to similar hippocampal epileptogenesis processes
About 1–2% of people worldwide suffer from epilepsy, which is characterized by unpredictable and intermittent seizure occurrence. Despite the fact that the exact origin of temporal lobe epilepsy is frequently unknown, it is frequently linked to an early triggering insult like brain damage, tumors, o...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123000490 |
| _version_ | 1797383681364459520 |
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| author | Victor R. Santos Cristiane Q. Tilelli Artur Fernandes Olagide Wagner de Castro Flávio Del-Vecchio Norberto Garcia-Cairasco |
| author_facet | Victor R. Santos Cristiane Q. Tilelli Artur Fernandes Olagide Wagner de Castro Flávio Del-Vecchio Norberto Garcia-Cairasco |
| author_sort | Victor R. Santos |
| collection | DOAJ |
| description | About 1–2% of people worldwide suffer from epilepsy, which is characterized by unpredictable and intermittent seizure occurrence. Despite the fact that the exact origin of temporal lobe epilepsy is frequently unknown, it is frequently linked to an early triggering insult like brain damage, tumors, or Status Epilepticus (SE). We used an experimental approach consisting of electrical stimulation of the amygdaloid complex to induce two behaviorally and structurally distinct SE states: Type I (fully convulsive), with more severe seizure behaviors and more extensive brain damage, and Type II (partial convulsive), with less severe seizure behaviors and brain damage. Our goal was to better understand how the various types of SE impact the hippocampus leading to the development of epilepsy. Despite clear variations between the two behaviors in terms of neurodegeneration, study of neurogenesis revealed a comparable rise in the number of Ki-67 + cells and an increase in Doublecortin (DCX) in both kinds of SE. |
| first_indexed | 2024-03-08T21:24:33Z |
| format | Article |
| id | doaj.art-c6a13b308f504f48b4ee2913ca2865ad |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-08T21:24:33Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-c6a13b308f504f48b4ee2913ca2865ad2023-12-21T07:38:21ZengElsevierIBRO Neuroscience Reports2667-24212023-12-01156876Different types of Status Epilepticus may lead to similar hippocampal epileptogenesis processesVictor R. Santos0Cristiane Q. Tilelli1Artur Fernandes2Olagide Wagner de Castro3Flávio Del-Vecchio4Norberto Garcia-Cairasco5Department of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil; Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, MG, Brazil; Correspondence to: Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.Department of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil; Campus Centro-Oeste Dona Lindu, Federal University of São João Del Rey, Divinópolis, MG, BrazilDepartment of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, BrazilDepartment of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil; Department of Pharmacology and Physiology, Universidade Federal de Alagoas, Maceió, AL, BrazilDepartment of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, BrazilDepartment of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil; Correspondence to: Ribeirão Preto School of Medicine, University of São Paulo Ribeirão Preto, 14049-900, Brazil.About 1–2% of people worldwide suffer from epilepsy, which is characterized by unpredictable and intermittent seizure occurrence. Despite the fact that the exact origin of temporal lobe epilepsy is frequently unknown, it is frequently linked to an early triggering insult like brain damage, tumors, or Status Epilepticus (SE). We used an experimental approach consisting of electrical stimulation of the amygdaloid complex to induce two behaviorally and structurally distinct SE states: Type I (fully convulsive), with more severe seizure behaviors and more extensive brain damage, and Type II (partial convulsive), with less severe seizure behaviors and brain damage. Our goal was to better understand how the various types of SE impact the hippocampus leading to the development of epilepsy. Despite clear variations between the two behaviors in terms of neurodegeneration, study of neurogenesis revealed a comparable rise in the number of Ki-67 + cells and an increase in Doublecortin (DCX) in both kinds of SE.http://www.sciencedirect.com/science/article/pii/S2667242123000490Temporal Lobe EpilepsyNeurodegenerationAbnormal Hippocampal NeurogenesisHippocampus |
| spellingShingle | Victor R. Santos Cristiane Q. Tilelli Artur Fernandes Olagide Wagner de Castro Flávio Del-Vecchio Norberto Garcia-Cairasco Different types of Status Epilepticus may lead to similar hippocampal epileptogenesis processes IBRO Neuroscience Reports Temporal Lobe Epilepsy Neurodegeneration Abnormal Hippocampal Neurogenesis Hippocampus |
| title | Different types of Status Epilepticus may lead to similar hippocampal epileptogenesis processes |
| title_full | Different types of Status Epilepticus may lead to similar hippocampal epileptogenesis processes |
| title_fullStr | Different types of Status Epilepticus may lead to similar hippocampal epileptogenesis processes |
| title_full_unstemmed | Different types of Status Epilepticus may lead to similar hippocampal epileptogenesis processes |
| title_short | Different types of Status Epilepticus may lead to similar hippocampal epileptogenesis processes |
| title_sort | different types of status epilepticus may lead to similar hippocampal epileptogenesis processes |
| topic | Temporal Lobe Epilepsy Neurodegeneration Abnormal Hippocampal Neurogenesis Hippocampus |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123000490 |
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