Population-level interventions for the primary prevention of dementia: a complex evidence review
Summary: Dementia risk reduction is a global public health priority. Existing primary prevention approaches have favored individual-level interventions, with a research and policy gap for population-level interventions. We conducted a complex, multi-stage, evidence review to identify empirical evide...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
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| Series: | EClinicalMedicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537024001172 |
| _version_ | 1827321184009584640 |
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| author | Sebastian Walsh Lindsay Wallace Isla Kuhn Oliver Mytton Louise Lafortune Wendy Wills Naaheed Mukadam Carol Brayne |
| author_facet | Sebastian Walsh Lindsay Wallace Isla Kuhn Oliver Mytton Louise Lafortune Wendy Wills Naaheed Mukadam Carol Brayne |
| author_sort | Sebastian Walsh |
| collection | DOAJ |
| description | Summary: Dementia risk reduction is a global public health priority. Existing primary prevention approaches have favored individual-level interventions, with a research and policy gap for population-level interventions. We conducted a complex, multi-stage, evidence review to identify empirical evidence on population-level interventions for each of the modifiable risk factors identified by the Lancet Commission on dementia (2020). Through a comprehensive series of targeted searches, we identified 4604 articles, of which 135 met our inclusion criteria. We synthesized evidence from multiple sources, including existing non-communicable disease prevention frameworks, and graded the consistency and comprehensiveness of evidence. We derived a population-level intervention framework for dementia risk reduction, containing 26 high- and moderate-confidence policy recommendations, supported by relevant information on effect sizes, sources of evidence, contextual information, and implementation guidance. This review provides policymakers with the evidence they need, in a useable format, to address this critical public health policy gap. Funding: SW is funded by a National Institute for Health and Care Research (NIHR) Doctoral Fellowship. WW and LF are part funded by the NIHR Applied Research Collaboration East of England. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. |
| first_indexed | 2024-04-25T01:00:53Z |
| format | Article |
| id | doaj.art-c6a1ddbd9b1f473aa6e114c74c823835 |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-04-25T01:00:53Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-c6a1ddbd9b1f473aa6e114c74c8238352024-03-11T04:11:02ZengElsevierEClinicalMedicine2589-53702024-04-0170102538Population-level interventions for the primary prevention of dementia: a complex evidence reviewSebastian Walsh0Lindsay Wallace1Isla Kuhn2Oliver Mytton3Louise Lafortune4Wendy Wills5Naaheed Mukadam6Carol Brayne7Cambridge Public Health, University of Cambridge, Cambridge CB2 0SR, UK; Corresponding author. Cambridge Public Health, Forvie Site, Robinson Way, Cambridge CB2 0SR, UK.Cambridge Public Health, University of Cambridge, Cambridge CB2 0SR, UKUniversity of Cambridge Medical School Library, School of Clinical Medicine, Cambridge CB2 0SP, UKGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UKCambridge Public Health, University of Cambridge, Cambridge CB2 0SR, UKCentre for Research in Public Health and Community Care, University of Hertfordshire, Hatfield AL10 9AB, UKDivision of Psychiatry, University College London, London W1T 7BN, UKCambridge Public Health, University of Cambridge, Cambridge CB2 0SR, UKSummary: Dementia risk reduction is a global public health priority. Existing primary prevention approaches have favored individual-level interventions, with a research and policy gap for population-level interventions. We conducted a complex, multi-stage, evidence review to identify empirical evidence on population-level interventions for each of the modifiable risk factors identified by the Lancet Commission on dementia (2020). Through a comprehensive series of targeted searches, we identified 4604 articles, of which 135 met our inclusion criteria. We synthesized evidence from multiple sources, including existing non-communicable disease prevention frameworks, and graded the consistency and comprehensiveness of evidence. We derived a population-level intervention framework for dementia risk reduction, containing 26 high- and moderate-confidence policy recommendations, supported by relevant information on effect sizes, sources of evidence, contextual information, and implementation guidance. This review provides policymakers with the evidence they need, in a useable format, to address this critical public health policy gap. Funding: SW is funded by a National Institute for Health and Care Research (NIHR) Doctoral Fellowship. WW and LF are part funded by the NIHR Applied Research Collaboration East of England. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.http://www.sciencedirect.com/science/article/pii/S2589537024001172 |
| spellingShingle | Sebastian Walsh Lindsay Wallace Isla Kuhn Oliver Mytton Louise Lafortune Wendy Wills Naaheed Mukadam Carol Brayne Population-level interventions for the primary prevention of dementia: a complex evidence review EClinicalMedicine |
| title | Population-level interventions for the primary prevention of dementia: a complex evidence review |
| title_full | Population-level interventions for the primary prevention of dementia: a complex evidence review |
| title_fullStr | Population-level interventions for the primary prevention of dementia: a complex evidence review |
| title_full_unstemmed | Population-level interventions for the primary prevention of dementia: a complex evidence review |
| title_short | Population-level interventions for the primary prevention of dementia: a complex evidence review |
| title_sort | population level interventions for the primary prevention of dementia a complex evidence review |
| url | http://www.sciencedirect.com/science/article/pii/S2589537024001172 |
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