Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic Applications
Drug delivery to the anterior and posterior segment of eye remains a challenge. Nanoparticle-mediated drug delivery has indicated some promise. The presented review aims to summarize recent advancements in chitosan-based nanotherapies for ocular drug delivery and the challenges encountered during th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/12/4189 |
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| author | Riddhi Vichare Inyoung Garner Ryan J. Paulson Radouil Tzekov Nurettin Sahiner Siva K. Panguluri Subhra Mohapatra Shyam S. Mohapatra Ramesh Ayyala Kevin B. Sneed Manas R. Biswal |
| author_facet | Riddhi Vichare Inyoung Garner Ryan J. Paulson Radouil Tzekov Nurettin Sahiner Siva K. Panguluri Subhra Mohapatra Shyam S. Mohapatra Ramesh Ayyala Kevin B. Sneed Manas R. Biswal |
| author_sort | Riddhi Vichare |
| collection | DOAJ |
| description | Drug delivery to the anterior and posterior segment of eye remains a challenge. Nanoparticle-mediated drug delivery has indicated some promise. The presented review aims to summarize recent advancements in chitosan-based nanotherapies for ocular drug delivery and the challenges encountered during the process. Significant research using chitosan, a cationic linear polymer, is being conducted for ocular drug delivery. A vast number of publications exploit the mucoadhesive properties of the polymer, which arise due to interactions between the amino acids of chitosan and the sialic acid residues in mucous. The high degree of crosslinking in chitosan nanoparticles facilitates a dramatic increase in ocular drug retention of the desired drug, which subsequently helps in ocular penetration and improving the bioavailability of the drugs. A noted decrease in the initial burst of the drug is the basis for developing sustained drug release formulation using biodegradable and biocompatible chitosan polymer. In vitro as well as in vivo studies have indicated enhancement in the uptake, accumulation, and removal of chitosan nanoparticles from the site of delivery. In summary, chitosan- or modified-chitosan-based nanoparticles are being widely tested as drug carriers for treatment of bacterial and viral infections, glaucoma, age-related macular degeneration, and diabetic retinopathy. |
| first_indexed | 2024-03-10T19:04:31Z |
| format | Article |
| id | doaj.art-c6a2be4541d047d2acb50bb5ca1f27f9 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T19:04:31Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-c6a2be4541d047d2acb50bb5ca1f27f92023-11-20T04:13:52ZengMDPI AGApplied Sciences2076-34172020-06-011012418910.3390/app10124189Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic ApplicationsRiddhi Vichare0Inyoung Garner1Ryan J. Paulson2Radouil Tzekov3Nurettin Sahiner4Siva K. Panguluri5Subhra Mohapatra6Shyam S. Mohapatra7Ramesh Ayyala8Kevin B. Sneed9Manas R. Biswal10MSPN Graduate Programs, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USAMSPN Graduate Programs, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USAMSPN Graduate Programs, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USADepartment of Pharmacotherapeutics & Clinical Research, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USAMSPN Graduate Programs, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADrug delivery to the anterior and posterior segment of eye remains a challenge. Nanoparticle-mediated drug delivery has indicated some promise. The presented review aims to summarize recent advancements in chitosan-based nanotherapies for ocular drug delivery and the challenges encountered during the process. Significant research using chitosan, a cationic linear polymer, is being conducted for ocular drug delivery. A vast number of publications exploit the mucoadhesive properties of the polymer, which arise due to interactions between the amino acids of chitosan and the sialic acid residues in mucous. The high degree of crosslinking in chitosan nanoparticles facilitates a dramatic increase in ocular drug retention of the desired drug, which subsequently helps in ocular penetration and improving the bioavailability of the drugs. A noted decrease in the initial burst of the drug is the basis for developing sustained drug release formulation using biodegradable and biocompatible chitosan polymer. In vitro as well as in vivo studies have indicated enhancement in the uptake, accumulation, and removal of chitosan nanoparticles from the site of delivery. In summary, chitosan- or modified-chitosan-based nanoparticles are being widely tested as drug carriers for treatment of bacterial and viral infections, glaucoma, age-related macular degeneration, and diabetic retinopathy.https://www.mdpi.com/2076-3417/10/12/4189chitosannanoparticlesocular diseasesbiofabrication |
| spellingShingle | Riddhi Vichare Inyoung Garner Ryan J. Paulson Radouil Tzekov Nurettin Sahiner Siva K. Panguluri Subhra Mohapatra Shyam S. Mohapatra Ramesh Ayyala Kevin B. Sneed Manas R. Biswal Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic Applications Applied Sciences chitosan nanoparticles ocular diseases biofabrication |
| title | Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic Applications |
| title_full | Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic Applications |
| title_fullStr | Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic Applications |
| title_full_unstemmed | Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic Applications |
| title_short | Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic Applications |
| title_sort | biofabrication of chitosan based nanomedicines and its potential use for translational ophthalmic applications |
| topic | chitosan nanoparticles ocular diseases biofabrication |
| url | https://www.mdpi.com/2076-3417/10/12/4189 |
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