Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection
Mycoplasma pneumoniae, as one of the most common pathogens, usually causes upper respiratory tract infections and pneumonia in humans and animals. It accounts for 10% to 40% of community-acquired pneumonia in children. The alveolar epithelial cells (AECs) are the first barrier against pathogen infec...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1052020/full |
| _version_ | 1797849199828533248 |
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| author | Yazhi Xue Mengyao Wang Hongbing Han |
| author_facet | Yazhi Xue Mengyao Wang Hongbing Han |
| author_sort | Yazhi Xue |
| collection | DOAJ |
| description | Mycoplasma pneumoniae, as one of the most common pathogens, usually causes upper respiratory tract infections and pneumonia in humans and animals. It accounts for 10% to 40% of community-acquired pneumonia in children. The alveolar epithelial cells (AECs) are the first barrier against pathogen infections, triggering innate immune responses by recruiting and activating immune cells when pathogens invade into the lung. Alveolar macrophages (AMs) are the most plentiful innate immune cells in the lung, and are the first to initiate immune responses with pathogens invasion. The cross-talk between the alveolar epithelium and macrophages is necessary to maintain physiological homeostasis and to eradicate invaded pathogen by regulating immune responses during Mycoplasma pneumoniae infections. This review summarizes the communications between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infections, including cytokines-medicated communications, signal transduction by extracellular vesicles, surfactant associated proteins-medicated signal transmission and establishment of intercellular gap junction channels. |
| first_indexed | 2024-04-09T18:41:05Z |
| format | Article |
| id | doaj.art-c6a43d855c57411fbe3f109e467d08c0 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-09T18:41:05Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-c6a43d855c57411fbe3f109e467d08c02023-04-11T05:37:02ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-04-011310.3389/fcimb.2023.10520201052020Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infectionYazhi Xue0Mengyao Wang1Hongbing Han2Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing, ChinaInstitute of Thoracic Oncology and Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu, ChinaBeijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing, ChinaMycoplasma pneumoniae, as one of the most common pathogens, usually causes upper respiratory tract infections and pneumonia in humans and animals. It accounts for 10% to 40% of community-acquired pneumonia in children. The alveolar epithelial cells (AECs) are the first barrier against pathogen infections, triggering innate immune responses by recruiting and activating immune cells when pathogens invade into the lung. Alveolar macrophages (AMs) are the most plentiful innate immune cells in the lung, and are the first to initiate immune responses with pathogens invasion. The cross-talk between the alveolar epithelium and macrophages is necessary to maintain physiological homeostasis and to eradicate invaded pathogen by regulating immune responses during Mycoplasma pneumoniae infections. This review summarizes the communications between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infections, including cytokines-medicated communications, signal transduction by extracellular vesicles, surfactant associated proteins-medicated signal transmission and establishment of intercellular gap junction channels.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1052020/fullMycoplasma pneumoniaeepithelial cellsalveolar macrophagescytokinesextracellular vesicles |
| spellingShingle | Yazhi Xue Mengyao Wang Hongbing Han Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection Frontiers in Cellular and Infection Microbiology Mycoplasma pneumoniae epithelial cells alveolar macrophages cytokines extracellular vesicles |
| title | Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection |
| title_full | Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection |
| title_fullStr | Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection |
| title_full_unstemmed | Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection |
| title_short | Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection |
| title_sort | interaction between alveolar macrophages and epithelial cells during mycoplasma pneumoniae infection |
| topic | Mycoplasma pneumoniae epithelial cells alveolar macrophages cytokines extracellular vesicles |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1052020/full |
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