Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as Antimicrobials
A simple one-pot method is proposed for obtaining the colloidal nanohybrid structures of silver (gold) and zinc oxide as well as nanostructures doped with zinc ions. The copolymers of maleic acid were used for the stabilization of nanoheterostructures. To characterize the preparation, UV–Vis spectro...
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MDPI AG
2023-10-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/20/11121 |
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| author | Nadezhda A. Samoilova Maria A. Krayukhina Alexander V. Naumkin Alexander A. Korlyukov Nelya M. Anuchina Dmitry A. Popov |
| author_facet | Nadezhda A. Samoilova Maria A. Krayukhina Alexander V. Naumkin Alexander A. Korlyukov Nelya M. Anuchina Dmitry A. Popov |
| author_sort | Nadezhda A. Samoilova |
| collection | DOAJ |
| description | A simple one-pot method is proposed for obtaining the colloidal nanohybrid structures of silver (gold) and zinc oxide as well as nanostructures doped with zinc ions. The copolymers of maleic acid were used for the stabilization of nanoheterostructures. To characterize the preparation, UV–Vis spectroscopy, TEM, FTIR, XPS, and XRD were used. The bactericidal properties of the nanoheterostructures were studied in relation to the fungus <i>C. albicans</i> and the bacteria <i>E. coli</i> and <i>S. aureus</i>, used in planktonic form. In general, the samples containing nanosilver were the most active, and the preparations containing gold nanoparticles were the least active. The minimum inhibitory concentrations (MICs) of the Ag/ZnO samples, based on all copolymers, were in the ranges of 1.4–1.7 μg/mL for <i>C. albicans</i>, 2.9–6.8 μg/mL for <i>E. coli</i>, and 23–27 μg/mL for <i>S. aureus</i>; the MIC values of Au/ZnO samples were 472 μg/mL for <i>S. aureus</i> and 945 μg/mL for <i>C. albicans</i> and <i>E. coli</i>. The additional introduction of zinc cations into heterodimers had practically no effect on the antimicrobial properties of the composites. For all prepared composites and all tested microorganisms, the fractional inhibitory concentration indexes were in the range of 0.5–2.2, which indicates a close-to-additive contribution of the bioactive components in the samples used in the bactericidal process. |
| first_indexed | 2024-03-10T21:29:44Z |
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| language | English |
| last_indexed | 2024-03-10T21:29:44Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-c6a48e1c678949d093beb5e654eb4ee42023-11-19T15:28:55ZengMDPI AGApplied Sciences2076-34172023-10-0113201112110.3390/app132011121Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as AntimicrobialsNadezhda A. Samoilova0Maria A. Krayukhina1Alexander V. Naumkin2Alexander A. Korlyukov3Nelya M. Anuchina4Dmitry A. Popov5A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov St., 119334 Moscow, RussiaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov St., 119334 Moscow, RussiaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov St., 119334 Moscow, RussiaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov St., 119334 Moscow, RussiaA. N. Bakulev Center for Cardiovascular Surgery of the Russian Ministry of Health, 135 Rublyovskoye Shosse, 121552 Moscow, RussiaA. N. Bakulev Center for Cardiovascular Surgery of the Russian Ministry of Health, 135 Rublyovskoye Shosse, 121552 Moscow, RussiaA simple one-pot method is proposed for obtaining the colloidal nanohybrid structures of silver (gold) and zinc oxide as well as nanostructures doped with zinc ions. The copolymers of maleic acid were used for the stabilization of nanoheterostructures. To characterize the preparation, UV–Vis spectroscopy, TEM, FTIR, XPS, and XRD were used. The bactericidal properties of the nanoheterostructures were studied in relation to the fungus <i>C. albicans</i> and the bacteria <i>E. coli</i> and <i>S. aureus</i>, used in planktonic form. In general, the samples containing nanosilver were the most active, and the preparations containing gold nanoparticles were the least active. The minimum inhibitory concentrations (MICs) of the Ag/ZnO samples, based on all copolymers, were in the ranges of 1.4–1.7 μg/mL for <i>C. albicans</i>, 2.9–6.8 μg/mL for <i>E. coli</i>, and 23–27 μg/mL for <i>S. aureus</i>; the MIC values of Au/ZnO samples were 472 μg/mL for <i>S. aureus</i> and 945 μg/mL for <i>C. albicans</i> and <i>E. coli</i>. The additional introduction of zinc cations into heterodimers had practically no effect on the antimicrobial properties of the composites. For all prepared composites and all tested microorganisms, the fractional inhibitory concentration indexes were in the range of 0.5–2.2, which indicates a close-to-additive contribution of the bioactive components in the samples used in the bactericidal process.https://www.mdpi.com/2076-3417/13/20/11121copolymers of maleic acidone-pot synthesisAg/(Au)ZnO nanoheterostructuresantibacterial activity |
| spellingShingle | Nadezhda A. Samoilova Maria A. Krayukhina Alexander V. Naumkin Alexander A. Korlyukov Nelya M. Anuchina Dmitry A. Popov Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as Antimicrobials Applied Sciences copolymers of maleic acid one-pot synthesis Ag/(Au)ZnO nanoheterostructures antibacterial activity |
| title | Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as Antimicrobials |
| title_full | Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as Antimicrobials |
| title_fullStr | Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as Antimicrobials |
| title_full_unstemmed | Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as Antimicrobials |
| title_short | Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as Antimicrobials |
| title_sort | polymer stabilized silver gold zinc oxide nanoheterodimer structures as antimicrobials |
| topic | copolymers of maleic acid one-pot synthesis Ag/(Au)ZnO nanoheterostructures antibacterial activity |
| url | https://www.mdpi.com/2076-3417/13/20/11121 |
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