Comparing the Effect of Intravenous Acetaminophen (Apotel®) and Intravenous Morphine in Controlling the Pain of Forearm and Leg Fractures in Adults
Background: This study evaluated the analgesic and safety effects of intravenous acetaminophen versus intravenous morphine in management of pain in forearm and leg fractures. Methods: This study was a randomized double-blind clinical trial conducted on patients (15-60 years-old) with forearm and le...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2016-05-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/5407 |
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| author | Marzieh Mollaei Mehrdad Esmailian Farhad Heydari |
| author_facet | Marzieh Mollaei Mehrdad Esmailian Farhad Heydari |
| author_sort | Marzieh Mollaei |
| collection | DOAJ |
| description | Background: This study evaluated the analgesic and safety effects of intravenous acetaminophen versus intravenous morphine in management of pain in forearm and leg fractures.
Methods: This study was a randomized double-blind clinical trial conducted on patients (15-60 years-old) with forearm and leg fracture and moderate to severe pain (pain score of 4 or more). Patients were randomized in to two groups, then, 1 g of intravenous acetaminophen or 0.1 mg/kg morphine was infused in 100 ml normal saline to either acetaminophen or morphine group. The pain severity was measured by Numeric Rating scale on arrival and 30 minutes after drug administration. The adverse reactions were also recorded.
Findings: 55 patients were entered. There was no significant difference in analgesic effect between the Intravenous Acetaminophen and morphine groups (P = 0.140), but, there was a significant difference in side effects between the two groups. (P = 0.014).
Conclusion: Intravenous acetaminophen appears to provide a similar level of analgesic comparable to intravenous morphine in limb fracture, however, further larger studies are required. |
| first_indexed | 2024-03-12T20:27:39Z |
| format | Article |
| id | doaj.art-c6a561559aba491ea3cc887686bc1755 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T20:27:39Z |
| publishDate | 2016-05-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-c6a561559aba491ea3cc887686bc17552023-08-02T00:21:46ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2016-05-01343762932982185Comparing the Effect of Intravenous Acetaminophen (Apotel®) and Intravenous Morphine in Controlling the Pain of Forearm and Leg Fractures in AdultsMarzieh Mollaei0Mehrdad Esmailian1Farhad Heydari2Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Emergency Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Emergency Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: This study evaluated the analgesic and safety effects of intravenous acetaminophen versus intravenous morphine in management of pain in forearm and leg fractures. Methods: This study was a randomized double-blind clinical trial conducted on patients (15-60 years-old) with forearm and leg fracture and moderate to severe pain (pain score of 4 or more). Patients were randomized in to two groups, then, 1 g of intravenous acetaminophen or 0.1 mg/kg morphine was infused in 100 ml normal saline to either acetaminophen or morphine group. The pain severity was measured by Numeric Rating scale on arrival and 30 minutes after drug administration. The adverse reactions were also recorded. Findings: 55 patients were entered. There was no significant difference in analgesic effect between the Intravenous Acetaminophen and morphine groups (P = 0.140), but, there was a significant difference in side effects between the two groups. (P = 0.014). Conclusion: Intravenous acetaminophen appears to provide a similar level of analgesic comparable to intravenous morphine in limb fracture, however, further larger studies are required.http://jims.mui.ac.ir/index.php/jims/article/view/5407AcetaminophenMorphinePain managementEmergency department |
| spellingShingle | Marzieh Mollaei Mehrdad Esmailian Farhad Heydari Comparing the Effect of Intravenous Acetaminophen (Apotel®) and Intravenous Morphine in Controlling the Pain of Forearm and Leg Fractures in Adults مجله دانشکده پزشکی اصفهان Acetaminophen Morphine Pain management Emergency department |
| title | Comparing the Effect of Intravenous Acetaminophen (Apotel®) and Intravenous Morphine in Controlling the Pain of Forearm and Leg Fractures in Adults |
| title_full | Comparing the Effect of Intravenous Acetaminophen (Apotel®) and Intravenous Morphine in Controlling the Pain of Forearm and Leg Fractures in Adults |
| title_fullStr | Comparing the Effect of Intravenous Acetaminophen (Apotel®) and Intravenous Morphine in Controlling the Pain of Forearm and Leg Fractures in Adults |
| title_full_unstemmed | Comparing the Effect of Intravenous Acetaminophen (Apotel®) and Intravenous Morphine in Controlling the Pain of Forearm and Leg Fractures in Adults |
| title_short | Comparing the Effect of Intravenous Acetaminophen (Apotel®) and Intravenous Morphine in Controlling the Pain of Forearm and Leg Fractures in Adults |
| title_sort | comparing the effect of intravenous acetaminophen apotel r and intravenous morphine in controlling the pain of forearm and leg fractures in adults |
| topic | Acetaminophen Morphine Pain management Emergency department |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/5407 |
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