Association between Multiple Myeloma and Ulcerative Colitis: A Cross-Sectional Analysis
Background and Aims: Multiple myeloma (MM) is a plasma cell dyscrasia that is common among patients with autoimmune diseases. However, the association between ulcerative colitis (UC) and multiple myeloma (MM) is yet to be established. We aimed to evaluate the prevalence of MM among patients with UC...
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MDPI AG
2023-04-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/11/2/59 |
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| author | Ayrton Bangolo Sowmya Sagireddy Paul Desrochers Imane Laabidi Vignesh K. Nagesh Amer Jarri Imranjot Sekhon Youssef Laabidi Deeksha Muralidhar Adarshpreet Singh Paranjyothy R. P. Sanjeeva Damanpartap S. Sandhu Saba Salma Saad A. Khan Mir I. Ali Sung H. Kim Wardah Bajwa Angela C. Tai Assma Itani Kareem Ahmed Mevlut Ozmen Bhargav Hirpara Shruti M. Borse Simcha Weissman |
| author_facet | Ayrton Bangolo Sowmya Sagireddy Paul Desrochers Imane Laabidi Vignesh K. Nagesh Amer Jarri Imranjot Sekhon Youssef Laabidi Deeksha Muralidhar Adarshpreet Singh Paranjyothy R. P. Sanjeeva Damanpartap S. Sandhu Saba Salma Saad A. Khan Mir I. Ali Sung H. Kim Wardah Bajwa Angela C. Tai Assma Itani Kareem Ahmed Mevlut Ozmen Bhargav Hirpara Shruti M. Borse Simcha Weissman |
| author_sort | Ayrton Bangolo |
| collection | DOAJ |
| description | Background and Aims: Multiple myeloma (MM) is a plasma cell dyscrasia that is common among patients with autoimmune diseases. However, the association between ulcerative colitis (UC) and multiple myeloma (MM) is yet to be established. We aimed to evaluate the prevalence of MM among patients with UC in the United States. Methods: This cross-sectional cohort analysis used the National Inpatient Sample from 2015–2018 to assess the overall MM prevalence among patients with and without UC, and within specific demographic subgroups. Prevalences were compared using a logistic regression model controlling for sex and age. Results: The crude prevalence of MM among patients with UC (<i>n</i> = 1750) compared with patients without UC (<i>n</i> = 366,265) was 0.44% vs. 0.37%, respectively. Patients with UC had increased overall odds of having MM (odds ratio (OR), 1.26). Males with UC had higher prevalence of MM (53.7% vs. 46.3%, respectively) than females. Patients with UC and MM were more likely to be African American than White (15.6% vs. 9.2%, respectively). Patients with UC age >64 had a higher prevalence of MM than those aged below 65 (70.9% vs. 29.1%, respectively). Patients with UC who were obese (BMI > 30) had a higher prevalence of MM than those who were non-obese (12.6% vs. 8.3%). Conclusions: Overall, UC appears to be associated with MM. This association can be particularly observed in specific demographic groups, such as obese, African American males, or patients >64 years of age. Thus, a high degree of clinical suspicion for MM is warranted, even with minimal symptomatology, in patients with UC, in particular among elder, obese, and African American males. |
| first_indexed | 2024-03-11T02:35:13Z |
| format | Article |
| id | doaj.art-c6a6920e80834b77bd3351f864eedf62 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-11T02:35:13Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-c6a6920e80834b77bd3351f864eedf622023-11-18T10:01:49ZengMDPI AGDiseases2079-97212023-04-011125910.3390/diseases11020059Association between Multiple Myeloma and Ulcerative Colitis: A Cross-Sectional AnalysisAyrton Bangolo0Sowmya Sagireddy1Paul Desrochers2Imane Laabidi3Vignesh K. Nagesh4Amer Jarri5Imranjot Sekhon6Youssef Laabidi7Deeksha Muralidhar8Adarshpreet Singh9Paranjyothy R. P. Sanjeeva10Damanpartap S. Sandhu11Saba Salma12Saad A. Khan13Mir I. Ali14Sung H. Kim15Wardah Bajwa16Angela C. Tai17Assma Itani18Kareem Ahmed19Mevlut Ozmen20Bhargav Hirpara21Shruti M. Borse22Simcha Weissman23Department of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, University of Washington, Seattle, WA 98195, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USADepartment of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ 07047, USABackground and Aims: Multiple myeloma (MM) is a plasma cell dyscrasia that is common among patients with autoimmune diseases. However, the association between ulcerative colitis (UC) and multiple myeloma (MM) is yet to be established. We aimed to evaluate the prevalence of MM among patients with UC in the United States. Methods: This cross-sectional cohort analysis used the National Inpatient Sample from 2015–2018 to assess the overall MM prevalence among patients with and without UC, and within specific demographic subgroups. Prevalences were compared using a logistic regression model controlling for sex and age. Results: The crude prevalence of MM among patients with UC (<i>n</i> = 1750) compared with patients without UC (<i>n</i> = 366,265) was 0.44% vs. 0.37%, respectively. Patients with UC had increased overall odds of having MM (odds ratio (OR), 1.26). Males with UC had higher prevalence of MM (53.7% vs. 46.3%, respectively) than females. Patients with UC and MM were more likely to be African American than White (15.6% vs. 9.2%, respectively). Patients with UC age >64 had a higher prevalence of MM than those aged below 65 (70.9% vs. 29.1%, respectively). Patients with UC who were obese (BMI > 30) had a higher prevalence of MM than those who were non-obese (12.6% vs. 8.3%). Conclusions: Overall, UC appears to be associated with MM. This association can be particularly observed in specific demographic groups, such as obese, African American males, or patients >64 years of age. Thus, a high degree of clinical suspicion for MM is warranted, even with minimal symptomatology, in patients with UC, in particular among elder, obese, and African American males.https://www.mdpi.com/2079-9721/11/2/59multiple myelomaplasma cell dyscrasiaIBDulcerative colitiscross sectional analysis |
| spellingShingle | Ayrton Bangolo Sowmya Sagireddy Paul Desrochers Imane Laabidi Vignesh K. Nagesh Amer Jarri Imranjot Sekhon Youssef Laabidi Deeksha Muralidhar Adarshpreet Singh Paranjyothy R. P. Sanjeeva Damanpartap S. Sandhu Saba Salma Saad A. Khan Mir I. Ali Sung H. Kim Wardah Bajwa Angela C. Tai Assma Itani Kareem Ahmed Mevlut Ozmen Bhargav Hirpara Shruti M. Borse Simcha Weissman Association between Multiple Myeloma and Ulcerative Colitis: A Cross-Sectional Analysis Diseases multiple myeloma plasma cell dyscrasia IBD ulcerative colitis cross sectional analysis |
| title | Association between Multiple Myeloma and Ulcerative Colitis: A Cross-Sectional Analysis |
| title_full | Association between Multiple Myeloma and Ulcerative Colitis: A Cross-Sectional Analysis |
| title_fullStr | Association between Multiple Myeloma and Ulcerative Colitis: A Cross-Sectional Analysis |
| title_full_unstemmed | Association between Multiple Myeloma and Ulcerative Colitis: A Cross-Sectional Analysis |
| title_short | Association between Multiple Myeloma and Ulcerative Colitis: A Cross-Sectional Analysis |
| title_sort | association between multiple myeloma and ulcerative colitis a cross sectional analysis |
| topic | multiple myeloma plasma cell dyscrasia IBD ulcerative colitis cross sectional analysis |
| url | https://www.mdpi.com/2079-9721/11/2/59 |
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