Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts

Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts

Progenitors of the thoracic tracheal system of adult Drosophila (tracheoblasts) arrest in G2 during larval life and rekindle a mitotic program subsequently. G2 arrest is dependent on ataxia telangiectasia mutated and rad3-related kinase (ATR)-dependent phosphorylation of checkpoint kinase 1 (Chk1) t...

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Bibliographic Details
Main Authors: Amrutha Kizhedathu, Piyush Chhajed, Lahari Yeramala, Deblina Sain Basu, Tina Mukherjee, Kutti R Vinothkumar, Arjun Guha
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
Drosophila tracheoblasts
G2 arrest
ATR
Chk1/grapes
ROS
Duox
Online Access:https://elifesciences.org/articles/68636

Internet

https://elifesciences.org/articles/68636

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