Do gabapentin or pregabalin directly modulate the µ receptor?

Do gabapentin or pregabalin directly modulate the µ receptor?

Background Pregabalin and gabapentin improve neuropathic pain symptoms but there are emerging concerns regarding their misuse. This is more pronounced among patients with substance use disorder, particularly involving opioids. Co-ingestion of gabapentinoids with opioids is increasingly identified in...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Preeti Manandhar, Bridin Patricia Murnion, Natasha L. Grimsey, Mark Connor, Marina Santiago
Format:	Article
Sprog:	English
Udgivet:	PeerJ Inc. 2021-04-01
Serier:	PeerJ
Fag:	Pregabalin Gabapentin Opioid µ receptor Overdose Gabapentinoids
Online adgang:	https://peerj.com/articles/11175.pdf

Lignende værker

Gabapentin and pregabalin exposures reported to United States poison centers, 2012–2022
af: Emily J.R. Carter, et al.
Udgivet: (2024-11-01)

A Systematic Review of the Clinical Use of Gabapentin and Pregabalin in Bipolar Disorder
af: Qin Xiang Ng, et al.
Udgivet: (2021-08-01)

Efficacy and safety of pregabalin and gabapentin in spinal stenosis: a systematic review and meta-analysis
af: Telmo Martínez, et al.
Udgivet: (2023-11-01)

Characterization of hospitalized patients who received naloxone while receiving opioids with or without gabapentinoids
af: Payal H. Desai, PharmD, BCCCP, et al.
Udgivet: (2021-07-01)

Gabapentin and Pregabalin in chronic neuropathic pain: cost efficacy evaluation
af: Paolo Marchettini, et al.
Udgivet: (2005-05-01)

Effects of pregabalin and gabapentin on postoperative pain and opioid consumption after laparoscopic cholecystectomy
af: Mohammad Eidy, et al.
Udgivet: (2017-08-01)

Comparative study of gabapentin versus pregabalin as a premedication in patients undergoing FESS under general anaesthesia
af: Girisha CN, et al.
Udgivet: (2022-06-01)

The effect of gabapentin and pregabalin administration on memory in clinical and preclinical studies: a meta-analysis and systematic review
af: Zahra Behroozi, et al.
Udgivet: (2023-04-01)

Comparison of Pregabalin and Gabapentin as Pre-emptive Analgesics in Patients Undergoing Abdominal Surgeries
af: Hafiz Ahmed Hassam Bhalli, et al.
Udgivet: (2023-04-01)

Prescribing trends of gabapentin, pregabalin, and oxycodone: a secondary analysis of primary care prescribing patterns in England
af: Katlyn Green, et al.
Udgivet: (2019-09-01)

A randomized controlled trial to compare pregabalin with gabapentin for postoperative pain in abdominal hysterectomy
af: Anju Ghai, et al.
Udgivet: (2011-01-01)

Preclinic and clinic effectiveness of gabapentin and pregabalin for treatment of neuropathic pain in rats and diabetic patients
af: Slavina Surcheva, et al.
Udgivet: (2017-05-01)

Comparing the effect of pregabalin, gabapentin, and acetaminophen on post-dural puncture headache
af: Alireza Mahoori, et al.
Udgivet: (2014-01-01)

A Dyskinesia Case Induced by Pramipexole, Pregabalin and Gabapentin After Cardiopulmonary Resuscitation
af: Dürdane Aksoy, et al.
Udgivet: (2013-12-01)

Socio-demographic, clinical variables and pain among Egyptian patients of opioid use disorder with and without comorbid gabapentin use
af: Nahla Nagy, et al.
Udgivet: (2024-10-01)

Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy
af: Yiheng Pan, et al.
Udgivet: (2022-09-01)

Prospective, randomised, double blinded controlled trial of gabapentin and pregabalin as pre emptive analgesia in patients undergoing lower abdominal and limb surgery under spinal anaesthesia
af: Induja Rajendran, et al.
Udgivet: (2014-01-01)

Comparing the prophylactic effects of oral gabapentin, pregabalin, and celecoxib on postoperative pain management in orthopedic surgery of the lower extremity: A double-blind randomized controlled trial
af: Dorna Kheirabadi, et al.
Udgivet: (2020-01-01)

The effect of preemptive gabapentin and pregabalin on postoperative pain of septoplasty with and without turbinoplasty: a randomized triple-blind controlled clinical trial
af: Rohollah Abbasi, et al.
Udgivet: (2023-09-01)

A Comparison of Oral Gabapentin and Oral Pregabalin as Preemptive Analgesia for Orthopedic Surgery Under Spinal Anaesthesia
af: Jain Neena1 , Bankapur Rahul2 , Lamba Preeti3 , Saurav Singh4
Udgivet: (2021-08-01)

Comparing pregabalin and gabapentin for persistent neuropathic pain: A protocol for a pilot N-of-1 trial series
af: Guy Bashford, et al.
Udgivet: (2021-12-01)

Effect of gabapentin on length of stay, opioid use, and pain scores in posterior spinal fusion for adolescent idiopathic scoliosis: a retrospective review across a multi-hospital system
af: De-An Zhang, et al.
Udgivet: (2023-01-01)

Pregabalin versus gabapentin in the treatment of sciatica: study protocol for a randomised, double-blind, cross-over trial (PAGPROS)
af: Kelvin Robertson, et al.
Udgivet: (2018-01-01)

Pregabalin as an effective treatment for acute postoperative pain following spinal surgery without major side effects: protocol for a prospective, randomized controlled, double-blinded trial
af: Ki-Hoon Park, et al.
Udgivet: (2023-06-01)

Rational dosing of gabapentin and pregabalin in chronic kidney disease
af: Raouf M, et al.
Udgivet: (2017-01-01)

A randomized trial comparing the efficacy of oral preemptive pregabalin and gabapentin for postoperative analgesia
af: T Krishna Prasad, et al.
Udgivet: (2023-01-01)

A comparative study to analyze the effect of gabapentin with amitriptyline versus pregabalin with amitriptyline in neuropathic pain in cancer patients undergoing palliative care
af: Nipun Lamba, et al.
Udgivet: (2022-01-01)

Risk of major adverse events associated with gabapentinoid and opioid combination therapy: A systematic review and meta-analysis
af: Jongsung Hahn, et al.
Udgivet: (2022-10-01)

Association of perioperative initiation of gabapentin versus pregabalin with kidney function: a target trial emulation study
af: Yanfang He, et al.
Udgivet: (2024-12-01)

Pregabalin prescribing patterns in Australian general practice, 2012–2018: a cross-sectional study
af: Andrea L Schaffer, et al.
Udgivet: (2021-01-01)

Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety
af: Víctor Mayoral, et al.
Udgivet: (2025-01-01)

The association between Gabapentin or Pregabalin use and the risk of dementia: an analysis of the National Health Insurance Research Database in Taiwan
af: Yu-Hua Huang, et al.
Udgivet: (2023-05-01)

Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial
af: Mohsin Qadeer, et al.
Udgivet: (2017-02-01)

Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study
af: Antunovic M, et al.
Udgivet: (2023-04-01)

Pregabalin and gabapentin for chronic low back pain without radiculopathy: a systematic review
af: Rafael Trindade Tatit, et al.
Udgivet: (2023-06-01)

Comparative evaluation between oral gabapentin and oral pregabalin premedication for attenuation of hemodynamic surge to laryngoscopy and endotracheal intubation in elective procedures under general anesthesia
af: Kunal Chandra Dubey, et al.
Udgivet: (2024-03-01)

Comparison of the effects of preoperative gabapentin and pregabalin on postoperative analgesic consumption, urinary retention and nausea-vomiting in patients undergoing anorectal surgery under spinal anesthesia
af: Tülin Arıcı, et al.
Udgivet: (2020-09-01)

Comparative efficacy and safety of gabapentin, pregabalin, oxcarbazepine, and duloxetine in diabetic peripheral neuropathy: A network meta-analysis
af: Karan Bhavesh Shah, et al.
Udgivet: (2024-10-01)

Pregabalin versus gabapentin nel trattamento dei pazienti con neuropatia periferica: adattamento di un modello internazionale per la valutazione di costo/efficacia e costo/utilità alla realtà nazionale
af: Paolo Marchettini, et al.
Udgivet: (2005-09-01)

Assessment of the Safety Signal for the Abuse Potential of Pregabalin and Gabapentin Using the FAERS Database and Big Data Search Analytics
af: Georgios Papazisis, et al.
Udgivet: (2021-05-01)