Do gabapentin or pregabalin directly modulate the µ receptor?

Do gabapentin or pregabalin directly modulate the µ receptor?

Background Pregabalin and gabapentin improve neuropathic pain symptoms but there are emerging concerns regarding their misuse. This is more pronounced among patients with substance use disorder, particularly involving opioids. Co-ingestion of gabapentinoids with opioids is increasingly identified in...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Preeti Manandhar, Bridin Patricia Murnion, Natasha L. Grimsey, Mark Connor, Marina Santiago
Format:	Artikel
Sprache:	English
Veröffentlicht:	PeerJ Inc. 2021-04-01
Schriftenreihe:	PeerJ
Schlagworte:	Pregabalin Gabapentin Opioid µ receptor Overdose Gabapentinoids
Online Zugang:	https://peerj.com/articles/11175.pdf

Ähnliche Einträge

Gabapentin and pregabalin exposures reported to United States poison centers, 2012–2022
von: Emily J.R. Carter, et al.
Veröffentlicht: (2024-11-01)

A Systematic Review of the Clinical Use of Gabapentin and Pregabalin in Bipolar Disorder
von: Qin Xiang Ng, et al.
Veröffentlicht: (2021-08-01)

Efficacy and safety of pregabalin and gabapentin in spinal stenosis: a systematic review and meta-analysis
von: Telmo Martínez, et al.
Veröffentlicht: (2023-11-01)

Characterization of hospitalized patients who received naloxone while receiving opioids with or without gabapentinoids
von: Payal H. Desai, PharmD, BCCCP, et al.
Veröffentlicht: (2021-07-01)

Gabapentin and Pregabalin in chronic neuropathic pain: cost efficacy evaluation
von: Paolo Marchettini, et al.
Veröffentlicht: (2005-05-01)

Effects of pregabalin and gabapentin on postoperative pain and opioid consumption after laparoscopic cholecystectomy
von: Mohammad Eidy, et al.
Veröffentlicht: (2017-08-01)

Comparison of pregabalin with gabapentin as preemptive analgesic in lumbar spine surgery
von: Sidharth S Routray, et al.
Veröffentlicht: (2018-01-01)

Early Administration of Gabapentinoids Improves Motor Recovery after Human Spinal Cord Injury
von: Freda M. Warner, et al.
Veröffentlicht: (2017-02-01)

Comparative study of gabapentin versus pregabalin as a premedication in patients undergoing FESS under general anaesthesia
von: Girisha CN, et al.
Veröffentlicht: (2022-06-01)

The effect of gabapentin and pregabalin administration on memory in clinical and preclinical studies: a meta-analysis and systematic review
von: Zahra Behroozi, et al.
Veröffentlicht: (2023-04-01)

Comparison of Pregabalin and Gabapentin as Pre-emptive Analgesics in Patients Undergoing Abdominal Surgeries
von: Hafiz Ahmed Hassam Bhalli, et al.
Veröffentlicht: (2023-04-01)

Abuse liability of gabapentin in the Saudi population after the pregabalin restriction: A cross-sectional study
von: Amina A. Alkhalaf, PharmD, et al.
Veröffentlicht: (2021-10-01)

Prescribing trends of gabapentin, pregabalin, and oxycodone: a secondary analysis of primary care prescribing patterns in England
von: Katlyn Green, et al.
Veröffentlicht: (2019-09-01)

A randomized controlled trial to compare pregabalin with gabapentin for postoperative pain in abdominal hysterectomy
von: Anju Ghai, et al.
Veröffentlicht: (2011-01-01)

Preclinic and clinic effectiveness of gabapentin and pregabalin for treatment of neuropathic pain in rats and diabetic patients
von: Slavina Surcheva, et al.
Veröffentlicht: (2017-05-01)

Comparing the effect of pregabalin, gabapentin, and acetaminophen on post-dural puncture headache
von: Alireza Mahoori, et al.
Veröffentlicht: (2014-01-01)

Preemptive Gabapentin vs Pregabalin for Acute Postoperative Pain after Surgery under Spinal Anaesthesia
von: V Saraswat, et al.
Veröffentlicht: (2008-01-01)

A Dyskinesia Case Induced by Pramipexole, Pregabalin and Gabapentin After Cardiopulmonary Resuscitation
von: Dürdane Aksoy, et al.
Veröffentlicht: (2013-12-01)

Socio-demographic, clinical variables and pain among Egyptian patients of opioid use disorder with and without comorbid gabapentin use
von: Nahla Nagy, et al.
Veröffentlicht: (2024-10-01)

Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy
von: Yiheng Pan, et al.
Veröffentlicht: (2022-09-01)

Prospective, randomised, double blinded controlled trial of gabapentin and pregabalin as pre emptive analgesia in patients undergoing lower abdominal and limb surgery under spinal anaesthesia
von: Induja Rajendran, et al.
Veröffentlicht: (2014-01-01)

Comparing the prophylactic effects of oral gabapentin, pregabalin, and celecoxib on postoperative pain management in orthopedic surgery of the lower extremity: A double-blind randomized controlled trial
von: Dorna Kheirabadi, et al.
Veröffentlicht: (2020-01-01)

Non-medical Use of Prescription Gabapentinoids (Gabapentin and Pregabalin) in Five European Countries
von: Francina Fonseca, et al.
Veröffentlicht: (2021-04-01)

The effect of preemptive gabapentin and pregabalin on postoperative pain of septoplasty with and without turbinoplasty: a randomized triple-blind controlled clinical trial
von: Rohollah Abbasi, et al.
Veröffentlicht: (2023-09-01)

A Comparison of Oral Gabapentin and Oral Pregabalin as Preemptive Analgesia for Orthopedic Surgery Under Spinal Anaesthesia
von: Jain Neena1 , Bankapur Rahul2 , Lamba Preeti3 , Saurav Singh4
Veröffentlicht: (2021-08-01)

Effect of gabapentin on length of stay, opioid use, and pain scores in posterior spinal fusion for adolescent idiopathic scoliosis: a retrospective review across a multi-hospital system
von: De-An Zhang, et al.
Veröffentlicht: (2023-01-01)

Comparing pregabalin and gabapentin for persistent neuropathic pain: A protocol for a pilot N-of-1 trial series
von: Guy Bashford, et al.
Veröffentlicht: (2021-12-01)

Pregabalin as an effective treatment for acute postoperative pain following spinal surgery without major side effects: protocol for a prospective, randomized controlled, double-blinded trial
von: Ki-Hoon Park, et al.
Veröffentlicht: (2023-06-01)

Pregabalin versus gabapentin in the treatment of sciatica: study protocol for a randomised, double-blind, cross-over trial (PAGPROS)
von: Kelvin Robertson, et al.
Veröffentlicht: (2018-01-01)

Rational dosing of gabapentin and pregabalin in chronic kidney disease
von: Raouf M, et al.
Veröffentlicht: (2017-01-01)

Comparative effects of chronic administrations of gabapentin, pregabalin and baclofen on rat memory using object recognition test
von: Asma Salimzade, et al.
Veröffentlicht: (2017-01-01)

A randomized trial comparing the efficacy of oral preemptive pregabalin and gabapentin for postoperative analgesia
von: T Krishna Prasad, et al.
Veröffentlicht: (2023-01-01)

A comparative study to analyze the effect of gabapentin with amitriptyline versus pregabalin with amitriptyline in neuropathic pain in cancer patients undergoing palliative care
von: Nipun Lamba, et al.
Veröffentlicht: (2022-01-01)

Pregabalin prescribing patterns in Australian general practice, 2012–2018: a cross-sectional study
von: Andrea L Schaffer, et al.
Veröffentlicht: (2021-01-01)

Association of perioperative initiation of gabapentin versus pregabalin with kidney function: a target trial emulation study
von: Yanfang He, et al.
Veröffentlicht: (2024-12-01)

Risk of major adverse events associated with gabapentinoid and opioid combination therapy: A systematic review and meta-analysis
von: Jongsung Hahn, et al.
Veröffentlicht: (2022-10-01)

Tapentadol shows lower intrinsic efficacy at µ receptor than morphine and oxycodone
von: Preeti Manandhar, et al.
Veröffentlicht: (2022-02-01)

Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study
von: Antunovic M, et al.
Veröffentlicht: (2023-04-01)

Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety
von: Víctor Mayoral, et al.
Veröffentlicht: (2025-01-01)

The association between Gabapentin or Pregabalin use and the risk of dementia: an analysis of the National Health Insurance Research Database in Taiwan
von: Yu-Hua Huang, et al.
Veröffentlicht: (2023-05-01)