Phylogenetic analysis reveals two genotypes of the emerging fungus Mucor indicus, an opportunistic human pathogen in immunocompromised patients
Mucormycosis is a rare fungal infection caused by Mucor indicus. Phylogenetic analysis of many M. indicus isolates, mainly sampled from different clinical and environmental specimens collected worldwide, revealed two genotypes, I and II, based on ITS and D1/D2 LSU rDNA sequences. A retrospective rev...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1038/emi.2017.51 |
| _version_ | 1797676905746399232 |
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| author | Saad J Taj-Aldeen Muna Almaslamani Bart Theelen Teun Boekhout |
| author_facet | Saad J Taj-Aldeen Muna Almaslamani Bart Theelen Teun Boekhout |
| author_sort | Saad J Taj-Aldeen |
| collection | DOAJ |
| description | Mucormycosis is a rare fungal infection caused by Mucor indicus. Phylogenetic analysis of many M. indicus isolates, mainly sampled from different clinical and environmental specimens collected worldwide, revealed two genotypes, I and II, based on ITS and D1/D2 LSU rDNA sequences. A retrospective review of the literature revealed 13 cases. Eight (76.9%) patients had disseminated infections, and the overall mortality rate was 30.7%. A pulmonary infection caused by M. indicus genotype I in a liver transplant recipient was disseminated to include the skin and was successfully treated with liposomal amphotericin B and aggressive surgery. M. indicus can infect a wide variety of patients with no real preference for the site of infection. We concluded that M. indicus has emerged as a significant cause of invasive mycosis in severely immunocompromised patients worldwide. Early diagnosis and initiation of appropriate therapy could enhance survival in these immunocompromised patient populations.Emerging Microbes & Infections (2017) 6, e63; doi:10.1038/emi.2017.51; published online 12 July 2017 |
| first_indexed | 2024-03-11T22:37:14Z |
| format | Article |
| id | doaj.art-c6ab30766aaa4950beec4339a81209e3 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-11T22:37:14Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-c6ab30766aaa4950beec4339a81209e32023-09-22T12:08:35ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512017-01-01611710.1038/emi.2017.51Phylogenetic analysis reveals two genotypes of the emerging fungus Mucor indicus, an opportunistic human pathogen in immunocompromised patientsSaad J Taj-Aldeen0Muna Almaslamani1Bart Theelen2Teun Boekhout3Mycology Unit, Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, PO Box 3050, Doha, QatarWeill Cornell Medicine-Qatar, Education City, PO Box 24144, Doha, QatarWesterdijk Fungal Biodiversity Institute (formerly CBS Fungal Biodiversity Centre), 3584 CT, Utrecht, The NetherlandsWesterdijk Fungal Biodiversity Institute (formerly CBS Fungal Biodiversity Centre), 3584 CT, Utrecht, The NetherlandsMucormycosis is a rare fungal infection caused by Mucor indicus. Phylogenetic analysis of many M. indicus isolates, mainly sampled from different clinical and environmental specimens collected worldwide, revealed two genotypes, I and II, based on ITS and D1/D2 LSU rDNA sequences. A retrospective review of the literature revealed 13 cases. Eight (76.9%) patients had disseminated infections, and the overall mortality rate was 30.7%. A pulmonary infection caused by M. indicus genotype I in a liver transplant recipient was disseminated to include the skin and was successfully treated with liposomal amphotericin B and aggressive surgery. M. indicus can infect a wide variety of patients with no real preference for the site of infection. We concluded that M. indicus has emerged as a significant cause of invasive mycosis in severely immunocompromised patients worldwide. Early diagnosis and initiation of appropriate therapy could enhance survival in these immunocompromised patient populations.Emerging Microbes & Infections (2017) 6, e63; doi:10.1038/emi.2017.51; published online 12 July 2017https://www.tandfonline.com/doi/10.1038/emi.2017.51disseminated infectiongenotypesliposomal amphotericin Bliver transplantmucormycosisMucor indicus |
| spellingShingle | Saad J Taj-Aldeen Muna Almaslamani Bart Theelen Teun Boekhout Phylogenetic analysis reveals two genotypes of the emerging fungus Mucor indicus, an opportunistic human pathogen in immunocompromised patients Emerging Microbes and Infections disseminated infection genotypes liposomal amphotericin B liver transplant mucormycosis Mucor indicus |
| title | Phylogenetic analysis reveals two genotypes of the emerging fungus Mucor indicus, an opportunistic human pathogen in immunocompromised patients |
| title_full | Phylogenetic analysis reveals two genotypes of the emerging fungus Mucor indicus, an opportunistic human pathogen in immunocompromised patients |
| title_fullStr | Phylogenetic analysis reveals two genotypes of the emerging fungus Mucor indicus, an opportunistic human pathogen in immunocompromised patients |
| title_full_unstemmed | Phylogenetic analysis reveals two genotypes of the emerging fungus Mucor indicus, an opportunistic human pathogen in immunocompromised patients |
| title_short | Phylogenetic analysis reveals two genotypes of the emerging fungus Mucor indicus, an opportunistic human pathogen in immunocompromised patients |
| title_sort | phylogenetic analysis reveals two genotypes of the emerging fungus mucor indicus an opportunistic human pathogen in immunocompromised patients |
| topic | disseminated infection genotypes liposomal amphotericin B liver transplant mucormycosis Mucor indicus |
| url | https://www.tandfonline.com/doi/10.1038/emi.2017.51 |
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