On-Target Side Effects of Targeted Therapeutics of Cancer
The concept of precision medicine is based on the identification of hallmarks of cancer to exploit them as drug targets. The basic idea was that in this way the therapeutic modalities will be more effective and the side effects will be less. Since the majority of these novel modalities are not speci...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Pathology and Oncology Research |
| Subjects: | |
| Online Access: | https://www.por-journal.com/articles/10.3389/pore.2022.1610694/full |
| _version_ | 1797221033451716608 |
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| author | József Tímár Andrea Uhlyarik |
| author_facet | József Tímár Andrea Uhlyarik |
| author_sort | József Tímár |
| collection | DOAJ |
| description | The concept of precision medicine is based on the identification of hallmarks of cancer to exploit them as drug targets. The basic idea was that in this way the therapeutic modalities will be more effective and the side effects will be less. Since the majority of these novel modalities are not specific for a cancer-related biological process or a cancer-specific (mutant) target protein, it is not a surprise that we had to learn new type of side effects, because these therapeutics also affect physiological or pathological processes. Even more, in cases of some of these novel therapies we were able to discover new molecular mechanisms of physiological and pathological processes. Identification of the on-target side effects of targeted drugs can help to prevent the development of them or better manage the patients when emerge during cancer therapy. |
| first_indexed | 2024-04-24T12:59:00Z |
| format | Article |
| id | doaj.art-c6add08fa498404cb721cf0ad667cd3a |
| institution | Directory Open Access Journal |
| issn | 1532-2807 |
| language | English |
| last_indexed | 2024-04-24T12:59:00Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Pathology and Oncology Research |
| spelling | doaj.art-c6add08fa498404cb721cf0ad667cd3a2024-04-05T16:34:20ZengFrontiers Media S.A.Pathology and Oncology Research1532-28072022-09-012810.3389/pore.2022.16106941610694On-Target Side Effects of Targeted Therapeutics of CancerJózsef Tímár0Andrea Uhlyarik1Departments of Pathology, Forensic and Insurance Medicine, Semmelweis University, Budapest, HungaryInternal Medicine and Oncology, Semmelweis University, Budapest, HungaryThe concept of precision medicine is based on the identification of hallmarks of cancer to exploit them as drug targets. The basic idea was that in this way the therapeutic modalities will be more effective and the side effects will be less. Since the majority of these novel modalities are not specific for a cancer-related biological process or a cancer-specific (mutant) target protein, it is not a surprise that we had to learn new type of side effects, because these therapeutics also affect physiological or pathological processes. Even more, in cases of some of these novel therapies we were able to discover new molecular mechanisms of physiological and pathological processes. Identification of the on-target side effects of targeted drugs can help to prevent the development of them or better manage the patients when emerge during cancer therapy.https://www.por-journal.com/articles/10.3389/pore.2022.1610694/fullimmunotherapytarget therapybone therapyangiogenesis inhibitorside effectpathomechanism |
| spellingShingle | József Tímár Andrea Uhlyarik On-Target Side Effects of Targeted Therapeutics of Cancer Pathology and Oncology Research immunotherapy target therapy bone therapy angiogenesis inhibitor side effect pathomechanism |
| title | On-Target Side Effects of Targeted Therapeutics of Cancer |
| title_full | On-Target Side Effects of Targeted Therapeutics of Cancer |
| title_fullStr | On-Target Side Effects of Targeted Therapeutics of Cancer |
| title_full_unstemmed | On-Target Side Effects of Targeted Therapeutics of Cancer |
| title_short | On-Target Side Effects of Targeted Therapeutics of Cancer |
| title_sort | on target side effects of targeted therapeutics of cancer |
| topic | immunotherapy target therapy bone therapy angiogenesis inhibitor side effect pathomechanism |
| url | https://www.por-journal.com/articles/10.3389/pore.2022.1610694/full |
| work_keys_str_mv | AT jozseftimar ontargetsideeffectsoftargetedtherapeuticsofcancer AT andreauhlyarik ontargetsideeffectsoftargetedtherapeuticsofcancer |