Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries
Peripheral nerve injuries requiring surgical repair affect over 100,000 individuals in the US annually. Three accepted methods of peripheral repair include end-to-end, end-to-side, and side-to-side neurorrhaphy, each with its own set of indications. While it remains important to understand the speci...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1555 |
| _version_ | 1797620220133638144 |
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| author | Clifford T. Pereira Elise E. Hill Anastasiya Stasyuk Neil Parikh Jannat Dhillon Aijun Wang Andrew Li |
| author_facet | Clifford T. Pereira Elise E. Hill Anastasiya Stasyuk Neil Parikh Jannat Dhillon Aijun Wang Andrew Li |
| author_sort | Clifford T. Pereira |
| collection | DOAJ |
| description | Peripheral nerve injuries requiring surgical repair affect over 100,000 individuals in the US annually. Three accepted methods of peripheral repair include end-to-end, end-to-side, and side-to-side neurorrhaphy, each with its own set of indications. While it remains important to understand the specific circumstances in which each method is employed, a deeper understanding of the molecular mechanisms underlying the repair can add to the surgeon’s decision-making algorithm when considering each technique, as well as help decide nuances in technique such as the need for making epineurial versus perineurial windows, length and dept of the nerve window, and distance from target muscle. In addition, a thorough knowledge of individual factors that are active in a particular repair can help guide research into adjunct therapies. This paper serves to summarize the similarities and divergences of the three commonly used nerve repair strategies and the scope of molecular mechanisms and signal transduction pathways in nerve regeneration as well as to identify the gaps in knowledge that should be addressed if we are to improve clinical outcomes in our patients. |
| first_indexed | 2024-03-11T08:38:00Z |
| format | Article |
| id | doaj.art-c6b020e916fe44f684709c74cf8e4cac |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:38:00Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c6b020e916fe44f684709c74cf8e4cac2023-11-16T21:21:14ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124155510.3390/jcm12041555Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve InjuriesClifford T. Pereira0Elise E. Hill1Anastasiya Stasyuk2Neil Parikh3Jannat Dhillon4Aijun Wang5Andrew Li6Department of Surgery, University of California Davis Medical Center, Sacramento, CA 95817, USADepartment of Surgery, University of California Davis Medical Center, Sacramento, CA 95817, USASchool of Medicine, University of California Davis, Sacramento, CA 95817, USASchool of Medicine, Boston University, Boston, MA 02118, USABoston University, Boston, MA 02118, USADepartment of Surgery, University of California Davis Medical Center, Sacramento, CA 95817, USADepartment of Surgery, University of California Davis Medical Center, Sacramento, CA 95817, USAPeripheral nerve injuries requiring surgical repair affect over 100,000 individuals in the US annually. Three accepted methods of peripheral repair include end-to-end, end-to-side, and side-to-side neurorrhaphy, each with its own set of indications. While it remains important to understand the specific circumstances in which each method is employed, a deeper understanding of the molecular mechanisms underlying the repair can add to the surgeon’s decision-making algorithm when considering each technique, as well as help decide nuances in technique such as the need for making epineurial versus perineurial windows, length and dept of the nerve window, and distance from target muscle. In addition, a thorough knowledge of individual factors that are active in a particular repair can help guide research into adjunct therapies. This paper serves to summarize the similarities and divergences of the three commonly used nerve repair strategies and the scope of molecular mechanisms and signal transduction pathways in nerve regeneration as well as to identify the gaps in knowledge that should be addressed if we are to improve clinical outcomes in our patients.https://www.mdpi.com/2077-0383/12/4/1555peripheral nerve injurysurgical repairnerve coaptationmolecular mechanismsend-to-end coaptationend-to-side coaptation |
| spellingShingle | Clifford T. Pereira Elise E. Hill Anastasiya Stasyuk Neil Parikh Jannat Dhillon Aijun Wang Andrew Li Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries Journal of Clinical Medicine peripheral nerve injury surgical repair nerve coaptation molecular mechanisms end-to-end coaptation end-to-side coaptation |
| title | Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries |
| title_full | Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries |
| title_fullStr | Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries |
| title_full_unstemmed | Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries |
| title_short | Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries |
| title_sort | molecular basis of surgical coaptation techniques in peripheral nerve injuries |
| topic | peripheral nerve injury surgical repair nerve coaptation molecular mechanisms end-to-end coaptation end-to-side coaptation |
| url | https://www.mdpi.com/2077-0383/12/4/1555 |
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