Autoimmune manifestations in acute viralhepatitides
Aim. To study autoimmune reactions in patients with acute viral hepatitis A, B, and С in the dynamics of an infectious process. Materials and methods. 134 patients with acute viral hepatitides of various etiology were examined. Among them there were 36 patients with acute viral hepatitis A, 40 with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2003-11-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29680 |
| _version_ | 1818400889726042112 |
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| author | Ye V Volchkova M N Allenov К Т Umbetova I V Ivanovo S G Pak |
| author_facet | Ye V Volchkova M N Allenov К Т Umbetova I V Ivanovo S G Pak |
| author_sort | Ye V Volchkova |
| collection | DOAJ |
| description | Aim. To study autoimmune reactions in patients with acute viral hepatitis A, B, and С in the dynamics of an infectious process.
Materials and methods. 134 patients with acute viral hepatitides of various etiology were examined.
Among them there were 36 patients with acute viral hepatitis A, 40 with B, and 58 with viral hepatitis С
Antinuclear antibodies (ANA), antismooth muscle antibodies (SMA), and antimitochondrial antibodies
(AMA) were determined by immunofluoresence assay using the test systems ATS COMVI-1, IMMCO
diagnostics (USA). Serum rheumatoid factor was detected by the semiquantitative latex-agglutination
test on a slide manufactured by the Human"firm (Germany). Cryoglobulins were identified by the
qualitative visual method.
Results. SMA, ANA were detected in the diagnostically significant titers (1:40-1:160) in patients with
acute viral hepatitis A, B, and С A distinction of autoimmune manifestations was ascertained in viral
hepatitis C. It has been demonstrated that in 71% of the patients cryoglobulins appear in the acute period of the disease and, in their presence, rheumatoid factor was found in 17.2% and 6.9% exhibited
anti-LKM-1 and AMA.
Conclusion. The presented data on the nature and time course of changes in autoimmune reactions in
patients with acute viral hepatitis A, B, and С during an infectious process suggest that autoimmune
disorders are characteristic of viral hepatic lesions just at the early stages of the disease irrespective of N 4.
its etiology and play a prominent role in the pathogenesis of these nosological entities. |
| first_indexed | 2024-12-14T07:43:45Z |
| format | Article |
| id | doaj.art-c6b26b7004294c9aa6bb5593d3652a56 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-14T07:43:45Z |
| publishDate | 2003-11-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-c6b26b7004294c9aa6bb5593d3652a562022-12-21T23:10:57Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422003-11-017811111426708Autoimmune manifestations in acute viralhepatitidesYe V VolchkovaM N AllenovК Т UmbetovaI V IvanovoS G PakAim. To study autoimmune reactions in patients with acute viral hepatitis A, B, and С in the dynamics of an infectious process. Materials and methods. 134 patients with acute viral hepatitides of various etiology were examined. Among them there were 36 patients with acute viral hepatitis A, 40 with B, and 58 with viral hepatitis С Antinuclear antibodies (ANA), antismooth muscle antibodies (SMA), and antimitochondrial antibodies (AMA) were determined by immunofluoresence assay using the test systems ATS COMVI-1, IMMCO diagnostics (USA). Serum rheumatoid factor was detected by the semiquantitative latex-agglutination test on a slide manufactured by the Human"firm (Germany). Cryoglobulins were identified by the qualitative visual method. Results. SMA, ANA were detected in the diagnostically significant titers (1:40-1:160) in patients with acute viral hepatitis A, B, and С A distinction of autoimmune manifestations was ascertained in viral hepatitis C. It has been demonstrated that in 71% of the patients cryoglobulins appear in the acute period of the disease and, in their presence, rheumatoid factor was found in 17.2% and 6.9% exhibited anti-LKM-1 and AMA. Conclusion. The presented data on the nature and time course of changes in autoimmune reactions in patients with acute viral hepatitis A, B, and С during an infectious process suggest that autoimmune disorders are characteristic of viral hepatic lesions just at the early stages of the disease irrespective of N 4. its etiology and play a prominent role in the pathogenesis of these nosological entities.https://ter-arkhiv.ru/0040-3660/article/view/29680acute viral hepatitisautoimmune manifestations |
| spellingShingle | Ye V Volchkova M N Allenov К Т Umbetova I V Ivanovo S G Pak Autoimmune manifestations in acute viralhepatitides Терапевтический архив acute viral hepatitis autoimmune manifestations |
| title | Autoimmune manifestations in acute viralhepatitides |
| title_full | Autoimmune manifestations in acute viralhepatitides |
| title_fullStr | Autoimmune manifestations in acute viralhepatitides |
| title_full_unstemmed | Autoimmune manifestations in acute viralhepatitides |
| title_short | Autoimmune manifestations in acute viralhepatitides |
| title_sort | autoimmune manifestations in acute viralhepatitides |
| topic | acute viral hepatitis autoimmune manifestations |
| url | https://ter-arkhiv.ru/0040-3660/article/view/29680 |
| work_keys_str_mv | AT yevvolchkova autoimmunemanifestationsinacuteviralhepatitides AT mnallenov autoimmunemanifestationsinacuteviralhepatitides AT ktumbetova autoimmunemanifestationsinacuteviralhepatitides AT ivivanovo autoimmunemanifestationsinacuteviralhepatitides AT sgpak autoimmunemanifestationsinacuteviralhepatitides |