Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03081-7 |
| _version_ | 1818992782110359552 |
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| author | Upneet K. Sokhi Mark P. Liber Laura Frye Sungho Park Kyuho Kang Tania Pannellini Baohong Zhao Rada Norinsky Lionel B. Ivashkiv Shiaoching Gong |
| author_facet | Upneet K. Sokhi Mark P. Liber Laura Frye Sungho Park Kyuho Kang Tania Pannellini Baohong Zhao Rada Norinsky Lionel B. Ivashkiv Shiaoching Gong |
| author_sort | Upneet K. Sokhi |
| collection | DOAJ |
| description | The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3. |
| first_indexed | 2024-12-20T20:31:38Z |
| format | Article |
| id | doaj.art-c6b3ebba7a6c4cca98a75c5a151f33d5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:31:38Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c6b3ebba7a6c4cca98a75c5a151f33d52022-12-21T19:27:20ZengNature PortfolioNature Communications2041-17232018-02-019111510.1038/s41467-018-03081-7Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse modelsUpneet K. Sokhi0Mark P. Liber1Laura Frye2Sungho Park3Kyuho Kang4Tania Pannellini5Baohong Zhao6Rada Norinsky7Lionel B. Ivashkiv8Shiaoching Gong9Arthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryResearch Division and Department of Pathology, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryRockefeller UniversityArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryThe human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.https://doi.org/10.1038/s41467-018-03081-7 |
| spellingShingle | Upneet K. Sokhi Mark P. Liber Laura Frye Sungho Park Kyuho Kang Tania Pannellini Baohong Zhao Rada Norinsky Lionel B. Ivashkiv Shiaoching Gong Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models Nature Communications |
| title | Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models |
| title_full | Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models |
| title_fullStr | Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models |
| title_full_unstemmed | Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models |
| title_short | Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models |
| title_sort | dissection and function of autoimmunity associated tnfaip3 a20 gene enhancers in humanized mouse models |
| url | https://doi.org/10.1038/s41467-018-03081-7 |
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