Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis
Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease, which comprise serious hazards to human health. Atherosclerosis is characterized by the deposition of lipids on the interior walls of blood vessels, causing an inflammatory respons...
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2020.564604/full |
| _version_ | 1818280479447580672 |
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| author | Qingyu Meng Luya Pu Xizi Luo Baisen Wang Fan Li Fan Li Fan Li Fan Li Fan Li Bin Liu |
| author_facet | Qingyu Meng Luya Pu Xizi Luo Baisen Wang Fan Li Fan Li Fan Li Fan Li Fan Li Bin Liu |
| author_sort | Qingyu Meng |
| collection | DOAJ |
| description | Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease, which comprise serious hazards to human health. Atherosclerosis is characterized by the deposition of lipids on the interior walls of blood vessels, causing an inflammatory response of immune cells, endothelial cells, and smooth muscle cells, and a proliferation cascade reaction. Despite years of research, the underlying pathogenesis of AS is not fully defined. Recent advances in our understanding of the molecular mechanisms by which non-coding RNA influences the initiation and progression of AS have shown that long non-coding RNAs (lncRNAs) regulate important stages in the atherosclerotic process. In this review, we summarize current knowledge of lncRNAs, which influence the development of AS. We review the regulatory processes of lncRNAs on core stages of atherosclerotic progression, including lipid metabolism, inflammation, vascular cell proliferation, apoptosis, adhesion and migration, and angiogenesis. A growing body of evidence suggests that lncRNAs have great potential as new therapeutic targets for the treatment of vascular diseases. |
| first_indexed | 2024-12-12T23:49:53Z |
| format | Article |
| id | doaj.art-c6b597684f09443c96e6e64aafd5264a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T23:49:53Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-c6b597684f09443c96e6e64aafd5264a2022-12-22T00:06:44ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-10-011110.3389/fphys.2020.564604564604Regulatory Roles of Related Long Non-coding RNAs in the Process of AtherosclerosisQingyu Meng0Luya Pu1Xizi Luo2Baisen Wang3Fan Li4Fan Li5Fan Li6Fan Li7Fan Li8Bin Liu9Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University, Changchun, ChinaDepartment of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University, Changchun, ChinaDepartment of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University, Changchun, ChinaDepartment of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University, Changchun, ChinaDepartment of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University, Changchun, ChinaThe Key Laboratory for Bionics Engineering, Ministry of Education, Jilin University, Changchun, ChinaEngineering Research Center for Medical Biomaterials of Jilin Province, Jilin University, Changchun, ChinaKey Laboratory for Health Biomedical Materials of Jilin Province, Jilin University, Changchun, ChinaState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang, ChinaCardiovascular Disease Center, The First Hospital of Jilin University, Changchun, ChinaAtherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease, which comprise serious hazards to human health. Atherosclerosis is characterized by the deposition of lipids on the interior walls of blood vessels, causing an inflammatory response of immune cells, endothelial cells, and smooth muscle cells, and a proliferation cascade reaction. Despite years of research, the underlying pathogenesis of AS is not fully defined. Recent advances in our understanding of the molecular mechanisms by which non-coding RNA influences the initiation and progression of AS have shown that long non-coding RNAs (lncRNAs) regulate important stages in the atherosclerotic process. In this review, we summarize current knowledge of lncRNAs, which influence the development of AS. We review the regulatory processes of lncRNAs on core stages of atherosclerotic progression, including lipid metabolism, inflammation, vascular cell proliferation, apoptosis, adhesion and migration, and angiogenesis. A growing body of evidence suggests that lncRNAs have great potential as new therapeutic targets for the treatment of vascular diseases.https://www.frontiersin.org/articles/10.3389/fphys.2020.564604/fulllncRNAatherosclerosisvascular cellslipid metabolisminflammatory responseangiogenesis |
| spellingShingle | Qingyu Meng Luya Pu Xizi Luo Baisen Wang Fan Li Fan Li Fan Li Fan Li Fan Li Bin Liu Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis Frontiers in Physiology lncRNA atherosclerosis vascular cells lipid metabolism inflammatory response angiogenesis |
| title | Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis |
| title_full | Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis |
| title_fullStr | Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis |
| title_full_unstemmed | Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis |
| title_short | Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis |
| title_sort | regulatory roles of related long non coding rnas in the process of atherosclerosis |
| topic | lncRNA atherosclerosis vascular cells lipid metabolism inflammatory response angiogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2020.564604/full |
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